A FACT about macroH2A removal in immune gene activation

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-08-22 DOI:10.1016/j.molcel.2024.07.028

Oliver Meers, Marcus Buschbeck

引用次数: 0

Abstract

Histone variants contribute to epigenetic regulation in development and disease but require the chaperone machinery for correct deposition. In this issue of Molecular Cell, Ji et al.¹ explain how the chaperone complex FACT removes the histone variant macroH2A1.2 and demonstrate its importance for gene activation in innate immune cells.

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关于免疫基因激活过程中去除宏 H2A 的事实

组蛋白变体有助于发育和疾病过程中的表观遗传调控，但需要伴侣机制才能正确沉积。在本期《分子细胞》（Molecular Cell）杂志上，Ji 等人1 解释了伴侣复合体 FACT 如何去除组蛋白变体 macroH2A1.2，并证明了它对先天性免疫细胞基因激活的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.