Comparison of obstetric and perinatal complications in intracytoplasmic sperm injection cycles with autologous oocytes and donated oocytes.

Revista da Associacao Medica Brasileira (1992) Pub Date : 2024-08-16 eCollection Date: 2024-01-01 DOI:10.1590/1806-9282.20240357
Valéria Cristina Datrino Horta, Renato Augusto Moreira de Sá, Marco Antônio Pessanha Lourenço, Raphael Datrino Horta, Rodrigo Datrino Horta, Luiz Guilherme Louzada Maldonado, Alberto Borges Peixoto, Edward Araujo Júnior
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Abstract

Objective: The aim of this study was to compare the obstetric and perinatal complications in women who became pregnant with autologous oocytes and those who received donated oocytes (DO) in intracytoplasmic sperm injection cycles (ICSI).

Methods: A retrospective cohort study was carried out by collecting data from medical records between 2019 and 2022. Only patients who underwent ICSI in an induced cycle using their own or freshly DO, with male infertility factor and tubal factor, were included.

Results: A total of 120 patients were assessed, comprising 51 cases utilizing their own oocytes (control group) and 69 cases employing DO (study group). Patients receiving DO (n=69) exhibited a significantly higher mean age compared to those utilizing their own oocytes (n=51) (41.96±2.16 vs 38.54±1.42 years, p<0.001). There was no significant association between the source of oocytes and gestational age at delivery (p=0.296), birth weight (p=0.836), admission to neonatal intensive care unit (ICU) (p=0.120), or maternal admission to adult ICU (p=0.767). Additionally, the origin of oocytes did not demonstrate any significant association with the risk of pre-eclampsia (p=0.357), gestational diabetes mellitus (p=0.187), premature rupture of membranes (p=0.996), uterine atony (p=0.996), placenta previa (p=0.393), oligohydramnios (p=0.393), or gestational hypertension (p=0.393)."

Conclusion: An increase in obstetric and perinatal complications was not observed in pregnancies with DO compared to pregnancies with autologous oocytes in women undergoing ICSI without prior comorbidities. Further studies with larger sample sizes are required to validate our findings.

比较使用自体卵母细胞和捐赠卵母细胞进行卵胞浆内单精子注射周期的产科和围产期并发症。
研究目的本研究旨在比较在卵胞浆内单精子显微注射周期(ICSI)中使用自体卵母细胞怀孕的妇女与接受捐赠卵母细胞(DO)怀孕的妇女的产科和围产期并发症:通过收集 2019 年至 2022 年期间的医疗记录数据,开展了一项回顾性队列研究。结果:共有120名患者接受了评估:共有120名患者接受了评估,其中51例使用自身卵母细胞(对照组),69例使用DO(研究组)。与使用自身卵母细胞的患者(51 例)相比,接受 DO 的患者(69 例)的平均年龄明显更高(41.96±2.16 岁 vs 38.54±1.42 岁,p):与使用自体卵母细胞的孕妇相比,使用DO的孕妇在接受ICSI时产科和围产期并发症并没有增加。要验证我们的研究结果,还需要进行样本量更大的进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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