Role of long noncoding RNAs in the regulation of alternative splicing in glioblastoma

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-08-19 DOI:10.1016/j.drudis.2024.104140

Bhupender Yadav , Pooja Yadav , Sunita Yadav , Amit Kumar Pandey

引用次数: 0

Abstract

Glioblastoma multiforme (GBM) is a highly severe primary brain tumor. Despite extensive research, effective treatments remain elusive. Long noncoding RNAs (lncRNAs) play a significant role in both cancer and normal biology. They influence alternative splicing (AS), which is crucial in cancer. Advances in lncRNA-specific microarrays and next-generation sequencing have enhanced understanding of AS. Abnormal AS contributes to cancer invasion, metastasis, apoptosis, therapeutic resistance, and tumor development, including glioma. lncRNA-mediated AS affects several cellular signaling pathways, promoting or suppressing cancer malignancy. This review discusses the lncRNAs regulating AS in glioblastoma and their mechanisms.

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长非编码 RNA 在胶质母细胞瘤替代剪接调控中的作用

多形性胶质母细胞瘤（GBM）是一种高度严重的原发性脑肿瘤。尽管进行了广泛的研究，但有效的治疗方法仍然难以捉摸。长非编码 RNA（lncRNA）在癌症和正常生物学中都扮演着重要角色。它们会影响替代剪接（AS），而替代剪接在癌症中至关重要。lncRNA特异性微阵列和下一代测序技术的进步加深了人们对AS的了解。异常的AS有助于癌症的侵袭、转移、凋亡、耐药性和肿瘤的发展，包括胶质瘤。lncRNA介导的AS会影响多种细胞信号通路，促进或抑制癌症的恶性发展。本综述讨论了调控胶质母细胞瘤中AS的lncRNA及其机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.