Harnessing the potential of mesenchymal stem cells–derived exosomes in degenerative diseases

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2024-06-01 DOI:10.1016/j.reth.2024.08.001

Hsiu-Jung Liao , Yi-Ping Yang , Yu-Hao Liu , Huan-Chin Tseng , Teh-Ia Huo , Shih-Hwa Chiou , Chih-Hung Chang

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引用次数: 0

Abstract

Mesenchymal stem cells (MSCs) have gained attention as a promising therapeutic approach in both preclinical and clinical osteoarthritis (OA) settings. Various joint cell types, such as chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and release extracellular vesicles (EVs), which subsequently influence the biological activities of recipient cells. Recently, extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have shown the potential to modulate various physiological and pathological processes through the modulation of cellular differentiation, immune responses, and tissue repair. This review explores the roles and therapeutic potential of MSC-EVs in OA and rheumatoid arthritis, cardiovascular disease, age-related macular degeneration, Alzheimer's disease, and other degenerative diseases. Notably, we provide a comprehensive summary of exosome biogenesis, microRNA composition, mechanisms of intercellular transfer, and their evolving role in the highlight of exosome-based treatments in both preclinical and clinical avenues.

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利用间充质干细胞衍生的外泌体在退行性疾病中的潜力

在临床前和临床骨关节炎（OA）治疗中，间充质干细胞（MSCs）作为一种很有前景的治疗方法受到了关注。各种关节细胞类型，如软骨细胞、滑膜成纤维细胞、成骨细胞和腱细胞，都能产生和释放细胞外囊泡 (EVs)，进而影响受体细胞的生物活性。最近，来自间充质干细胞的细胞外囊泡已显示出通过调节细胞分化、免疫反应和组织修复来调节各种生理和病理过程的潜力。这篇综述探讨了间充质干细胞-EV在OA和类风湿性关节炎、心血管疾病、老年性黄斑变性、阿尔茨海默病和其他退行性疾病中的作用和治疗潜力。值得注意的是，我们全面总结了外泌体的生物发生、microRNA组成、细胞间转移机制，以及它们在临床前和临床途径中基于外泌体的治疗亮点中不断发展的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.