Validation of Noninvasive Methemoglobin and Carboxyhemoglobin Measurements Using Pulse Co-Oximeter in Healthy Dogs.

IF 1.7 Q2 VETERINARY SCIENCES
Veterinary medicine (Auckland, N.Z.) Pub Date : 2024-08-16 eCollection Date: 2024-01-01 DOI:10.2147/VMRR.S465945
Jiwoong Her, Justin Roh, Deborah A Keys
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Abstract

Purpose: To assess the agreement between pulse co-oximeter and blood co-oximeter in measuring methemoglobin (MetHb) and carboxyhemoglobin (COHb) in healthy, awake dogs.

Patients and methods: Forty-five healthy dogs were enrolled in the study. Pulse co-oximetry was performed using the Masimo Radical 7 Pulse Co-Oximeter with a Rainbow® adhesive sensor. Simultaneously, venous blood samples were collected, and MetHb and COHb were immediately measured using a Stat Profile Prime Plus VET Critical Care Analyzer. Paired measurements of MetHb and COHb were evaluated via Spearman correlation, intra-class correlation (ICC), and Bland-Altman plots to evaluate the degree of agreement between the pulse co-oximeter and the blood co-oximeter.

Results: A total of 45 paired MetHb and COHb measurements were collected. There was a weak correlation between the pulse co-oximeter and the blood co-oximeter readings. The correlation coefficients for MetHb and COHb were 0.0 (95% CI, -0.3 to 0.3) and 0.03 (95% CI, -0.27 to 0.32), respectively. The ICC indicated poor agreement between the pulse and blood co-oximeter for MetHb (ICC = 0.00, 95% CI: -0.12 to 0.15) and COHb (ICC = 0.03, 95% CI: -0.27 to 0.33). Bland-Altman plots revealed low mean bias but wide limits of agreement, indicating that the pulse co-oximeter overestimated MetHb by on average of 0.7% (P < 0.0001) (95% LoA: -0.5 to 2.0) and COHb by on average 0.2% (P = 0.59) (95% LoA: -4.6 to 5.0).

Conclusion: Obtaining MetHb and COHb measurements with the Masimo Radical 7 Pulse Co-Oximeter is straightforward in healthy, awake dogs. However, the device does not provide accurate measurements compared to the blood co-oximeter, specifically in the range of MetHb and COHb in healthy dogs, based on the wide LoA.

使用脉冲共氧仪对健康犬进行无创高铁血红蛋白和碳氧血红蛋白测量的验证。
目的:评估脉搏同氧血红蛋白仪和血液同氧血红蛋白仪在测量清醒健康犬的高铁血红蛋白(MetHb)和碳氧血红蛋白(COHb)时的一致性:研究共招募了 45 只健康犬。使用带有 Rainbow® 黏附传感器的 Masimo Radical 7 脉搏同氧测量仪进行脉搏同氧测量。同时采集静脉血样本,并立即使用 Stat Profile Prime Plus VET 重症监护分析仪测量 MetHb 和 COHb。通过斯皮尔曼相关性、类内相关性 (ICC) 和 Bland-Altman 图对 MetHb 和 COHb 的配对测量结果进行评估,以评价脉搏同氧血氧计和血液同氧血氧计之间的一致程度:结果:共收集了 45 次成对的 MetHb 和 COHb 测量值。脉搏共氧仪和血液共氧仪读数之间的相关性较弱。MetHb和COHb的相关系数分别为0.0(95% CI,-0.3至0.3)和0.03(95% CI,-0.27至0.32)。ICC 显示脉搏和血液同氧血红蛋白测量仪对 MetHb(ICC = 0.00,95% CI:-0.12 至 0.15)和 COHb(ICC = 0.03,95% CI:-0.27 至 0.33)的测量结果一致性较差。Bland-Altman图显示平均偏差较低,但一致性范围较宽,表明脉搏同氧血红蛋白仪平均高估了0.7%的MetHb(P < 0.0001)(95% LoA:-0.5至2.0),平均高估了0.2%的COHb(P = 0.59)(95% LoA:-4.6至5.0):结论:使用 Masimo Radical 7 Pulse Co-Oximeter 对健康、清醒的狗进行 MetHb 和 COHb 测量非常简单。但是,与血液同氧仪相比,该设备不能提供准确的测量值,特别是在健康狗的 MetHb 和 COHb 范围内,因为 LoA 较宽。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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