Impact of rs599839 Polymorphism on Coronary Artery Disease Risk in Saudi Diabetic Patients.

4区医学 Q3 Medicine

Disease Markers Pub Date : 2024-08-07 eCollection Date: 2024-01-01 DOI:10.1155/2024/8278727

Neda M Bogari, Ahmad O Babalghith, Zohor Asaad Azher, Ahmad Hasan Mufti, Abdellatif Bouazzaoui, Hussain Banni, Abdulelah Awaji Madkhali, Ahmed Alahmadi, Reem M Allam

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引用次数: 0

Abstract

Background: Coronary artery diseases may be affected by several genetic and nongenetic factors. Single-nucleotide polymorphism (SNP) rs599839 and type 2 diabetes mellitus (T2DM) can affect the occurrence and severity of coronary artery disease (CAD).

Methods: Our aim was to investigate how T2DM and the rs599839 variant affected serum lipid levels and the degree of CAD patients' coronary artery stenosis. rs599839 polymorphism genotyping was done on Saudi patients with coronary angiography performed previously. Patients enrolled were divided into group A (360 DM patients), group B (225 DM patients with CAD), and group C (190 healthy volunteers as control).

Results: Individuals with diabetes and CAD who possessed the GG genotype in rs599839 exhibited markedly reduced means of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG; 224.5, 116.2, and 221.4 versus 251.6, 131.3, and 261.7 mg/dl, p=0.003, 0.007, and 0.025, respectively) than AA genotype. The odds ratio and the confidence interval of 95% for G allele carriers of rs599839 were OR = 0.62, 95% CI: 0.41-0.82, and p=0.003, among diabetic patients with CAD.

Conclusions: In patients with diabetic CAD, the locus 1p13.3 polymorphism rs599839 was found to be substantially correlated with serum lipid levels. Furthermore, among Saudi patients with diabetes, the G allele of rs599839 variant lowers the CAD risk.

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沙特糖尿病患者 rs599839 多态性对冠心病风险的影响

背景：冠状动脉疾病可能受到多种遗传和非遗传因素的影响。单核苷酸多态性（SNP）rs599839和2型糖尿病（T2DM）会影响冠状动脉疾病（CAD）的发生和严重程度：我们的目的是研究 T2DM 和 rs599839 变体如何影响血清脂质水平和 CAD 患者的冠状动脉狭窄程度。入组患者被分为 A 组（360 名糖尿病患者）、B 组（225 名患有 CAD 的糖尿病患者）和 C 组（190 名健康志愿者作为对照）：结果：与 AA 基因型相比，rs599839 基因型为 GG 的糖尿病和 CAD 患者的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG；分别为 224.5、116.2 和 221.4 对 251.6、131.3 和 261.7 mg/dl，P=0.003、0.007 和 0.025）均明显降低。在患有 CAD 的糖尿病患者中，rs599839 的 G 等位基因携带者的几率比和 95% 的置信区间分别为 OR = 0.62、95% CI：0.41-0.82 和 p=0.003：结论：在糖尿病并发心血管疾病患者中，1p13.3位点多态性rs599839与血清脂质水平密切相关。此外，在沙特籍糖尿病患者中，rs599839 变异的 G 等位基因可降低 CAD 风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Disease Markers 医学-病理学

自引率

0.00%

发文量

792

审稿时长

6-12 weeks

期刊介绍： Disease Markers is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the identification of disease markers, the elucidation of their role and mechanism, as well as their application in the prognosis, diagnosis and treatment of diseases.