Independent and joint relationships of cardiorespiratory fitness and body mass index with liver fat content.

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes, Obesity & Metabolism Pub Date : 2024-08-20 DOI:10.1111/dom.15847

Yu Jia, Yiheng Zhou, Yi Lei, Rui Zeng, Zhi Wan, Dongze Li, Qian Zhao, Xiaoyang Liao

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引用次数: 0

Abstract

Aims: To investigate the relationship between cardiorespiratory fitness (CRF) and liver fat content (LFC) in community-based participants and highlight their relationship in people with different body mass indices (BMIs).

Materials and methods: Using UK Biobank data, CRF was estimated with bicycle ergometer fitness testing and was evaluated based on physical work capacity at 75% maximum heart rate (PWC_75%). LFC was quantified through liver proton density fat fraction (PDFF) on magnetic resonance imaging. Multivariate linear regression models were used to analyse the associations of CRF and BMI with absolute reduction and percentage change in PDFF (%).

Results: In total, 5765 participants with a mean age of 55.57 years and a median (range) follow-up of 10.7 (4.0-17.7) years were included. Compared with the lowest PWC_75% tertile, the absolute reduction and percentage change in PDFF in the highest PWC_75% tertile were -0.450 (95% confidence interval [CI] -0.699 to -0.192) and -4.152 (95% CI -6.044 to -2.104), respectively. These associations were independent of BMI, and individuals with obesity and normal weight had the largest absolute reduction and percentage change in LFC, respectively (p for interaction <0.001). Joint analysis showed that PWC_75% and BMI had a negative dose-response relationship with PDFF. These associations were consistent in different sex and age subgroups (p for interaction >0.05).

Conclusions: There was a significant negative association between CRF and LFC, and this association was independent of BMI. The results of this study strongly recommend improving CRF to mitigate LFC.

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心肺功能和体重指数与肝脏脂肪含量的独立和共同关系。

目的：研究社区参与者的心肺功能（CRF）和肝脏脂肪含量（LFC）之间的关系，并强调它们在不同体重指数（BMI）人群中的关系：利用英国生物库数据，通过自行车测力计体能测试估算CRF，并根据75%最大心率下的体力工作能力（PWC75%）进行评估。LFC通过磁共振成像的肝质子密度脂肪分数（PDFF）进行量化。多变量线性回归模型用于分析 CRF 和 BMI 与 PDFF 绝对值和百分比变化（%）之间的关系：共纳入 5765 名参与者，平均年龄为 55.57 岁，随访中位数（范围）为 10.7（4.0-17.7）年。与 PWC75% 最低的三等分组相比，PWC75% 最高的三等分组的 PDFF 绝对减少量和百分比变化分别为-0.450（95% 置信区间 [CI] -0.699至-0.192）和-4.152（95% CI -6.044至-2.104）。这些关联与体重指数无关，肥胖者和体重正常者的 LFC 绝对减少量和百分比变化分别最大（p 为交互作用的 75%），体重指数与 PDFF 呈负剂量反应关系。这些关系在不同性别和年龄的亚组中是一致的（交互作用 p >0.05）：结论：CRF 与 LFC 之间存在明显的负相关，且这种关系与体重指数无关。本研究结果强烈建议改善 CRF 以减轻 LFC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.