Mohamad Yasmin, Steven H Marshall, Liang Chen, Daniel D Rhoads, Michael R Jacobs, Laura J Rojas, Federico Perez, Andrea M Hujer, Kristine M Hujer, David van Duin, Vance Fowler, Henry F Chambers, Barry N Kreiswirth, Robert A Bonomo
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引用次数: 0
Abstract
We characterized the molecular determinants of meropenem-vaborbactam (MV) non-susceptibility among non-metallo-β-lactamase-producing KPC-Klebsiella pneumoniae (KPC-KP). Whole-genome sequencing was performed to identify mutations associated with MV non-susceptibility. Isolates with elevated MV MICs were found to have mutations encoding truncated or altered OmpK36 porins and increased blaKPC copy numbers. KPC-KP isolates with decreased susceptibility to MV were detected among a collection of isolates predating the availability of MV.
期刊介绍:
Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.