Bicuspid Aortic Valve dilemma: TAVI or SAVR? Insights from the NOTION-2 trial.

IF 0.7 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Indian Journal of Thoracic and Cardiovascular Surgery Pub Date : 2024-09-01 Epub Date: 2024-08-05 DOI:10.1007/s12055-024-01809-3

Pradeep Narayan

引用次数: 0

Abstract

The Nordic Aortic Valve Intervention-2 (NOTION-2) trial is the first randomized controlled trial to compare transcatheter aortic valve implantation (TAVI) with surgical aortic valve replacement (SAVR) in low-risk patients, specifically focusing on relatively younger patients and those with bicuspid valves. It randomized 370 patients (mean age 71 years) to assess outcomes at 1 year. Results indicated a higher composite primary endpoint rate for TAVI (10.2%) compared to SAVR (7.1%) in the overall cohort, with even more pronounced differences in patients with bicuspid valves (14.3% for TAVI vs. 3.9% for SAVR). The risk of death or disabling stroke at 1 year was also three times higher with TAVI.

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二尖瓣主动脉瓣困境：TAVI 还是 SAVR？NOTION-2 试验的启示。

北欧主动脉瓣干预-2（NOTION-2）试验是第一项比较低风险患者经导管主动脉瓣植入术（TAVI）和外科主动脉瓣置换术（SAVR）的随机对照试验，特别关注相对年轻的患者和双尖瓣患者。该研究对 370 名患者（平均年龄 71 岁）进行了随机分组，以评估 1 年后的疗效。结果显示，在整个队列中，TAVI（10.2%）的复合主要终点率高于 SAVR（7.1%），而在双尖瓣患者中差异更为明显（TAVI 为 14.3%，SAVR 为 3.9%）。TAVI术后1年死亡或致残性中风的风险也比SAVR术高3倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Thoracic and Cardiovascular Surgery CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

1.20

自引率

14.30%

发文量

141

期刊介绍： The primary aim of the Indian Journal of Thoracic and Cardiovascular Surgery is education. The journal aims to dissipate current clinical practices and developments in the area of cardiovascular and thoracic surgery. This includes information on cardiovascular epidemiology, aetiopathogenesis, clinical manifestation etc. The journal accepts manuscripts from cardiovascular anaesthesia, cardiothoracic and vascular nursing and technology development and new/innovative products.The journal is the official publication of the Indian Association of Cardiovascular and Thoracic Surgeons which has a membership of over 1000 at present.DescriptionThe journal is the official organ of the Indian Association of Cardiovascular-Thoracic Surgeons. It was started in 1982 by Dr. Solomon Victor and ws being published twice a year up to 1996. From 2000 the editorial office moved to Delhi. From 2001 the journal was extended to quarterly and subsequently four issues annually have been printed out at time and regularly without fail. The journal receives manuscripts from members and non-members and cardiovascular surgeons. The manuscripts are peer reviewed by at least two or sometimes three or four reviewers who are on the panel. The manuscript process is now completely online. Funding the journal comes partially from the organization and from revenue generated by subscription and advertisement.