Adjuvant-independent airway sensitization and infection mouse models leading to allergic asthma.

IF 3.3 Q2 ALLERGY
Frontiers in allergy Pub Date : 2024-08-02 eCollection Date: 2024-01-01 DOI:10.3389/falgy.2024.1423938
Mariem Radhouani, Philipp Starkl
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引用次数: 0

Abstract

Asthma is a chronic respiratory disease of global importance. Mouse models of allergic asthma have been instrumental in advancing research and novel therapeutic strategies for patients. The application of relevant allergens and physiological routes of exposure in such models has led to valuable insights into the complexities of asthma onset and development as well as key disease mechanisms. Furthermore, environmental microbial exposures and infections have been shown to play a fundamental part in asthma pathogenesis and alter disease outcome. In this review, we delve into physiological mouse models of allergic asthma and explore literature reports on most significant interplays between microbial infections and asthma development with relevance to human disease.

导致过敏性哮喘的不依赖佐剂的气道致敏和感染小鼠模型。
哮喘是一种全球性的慢性呼吸道疾病。过敏性哮喘小鼠模型在推动研究和为患者制定新型治疗策略方面发挥了重要作用。在这些模型中应用相关过敏原和生理接触途径,有助于深入了解哮喘发病和发展的复杂性以及关键疾病机制。此外,环境中的微生物暴露和感染已被证明在哮喘发病机制中起着根本性的作用,并改变着疾病的预后。在这篇综述中,我们将深入研究过敏性哮喘的生理小鼠模型,并探讨微生物感染与哮喘发病之间最重要的相互作用以及与人类疾病相关的文献报道。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.80
自引率
0.00%
发文量
0
审稿时长
12 weeks
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