Changes of the peripapillary vascular parameters in premature infants without retinopathy of prematurity using U-net segmentation.

IF 1.9 4区医学 Q2 OPHTHALMOLOGY

International journal of ophthalmology Pub Date : 2024-08-18 eCollection Date: 2024-01-01 DOI:10.18240/ijo.2024.08.10

Shuai Liu, Lei Liu, Cui-Xia Ma, Liu-Hui Huang, Bin Li

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引用次数: 0

Abstract

Aim: To quantitatively assess the changes in mean vascular tortuosity (mVT) and mean vascular width (mVW) around the optic disc and their correlation with gestational age (GA) and birth weight (BW) in premature infants without retinopathy of prematurity (ROP).

Methods: A single-center retrospective study included a total of 133 (133 eyes) premature infants [mean corrected gestational age (CGA) 43.6wk] without ROP as the premature group and 130 (130 eyes) CGA-matched full-term infants as the control group. The peripapillary mVT and mVW were quantitatively measured using computer-assisted techniques.

Results: Premature infants had significantly higher mVT (P=0.0032) and lower mVW (P=0.0086) by 2.68 (10⁴ cm^-3) and 1.85 µm, respectively. Subgroup analysis with GA showed significant differences (P=0.0244) in mVT between the early preterm and middle to late preterm groups, but the differences between mVW were not significant (P=0.6652). The results of the multiple linear regression model showed a significant negative correlation between GA and BW with mVT after adjusting sex and CGA (P=0.0211 and P=0.0006, respectively). For each day increase in GA at birth, mVT decreased by 0.1281 (10⁴ cm^-3) and for each 1 g increase in BW, mVT decreased by 0.006 (10⁴ cm^-3). However, GA (P=0.9402) and BW (P=0.7275) were not significantly correlated with mVW.

Conclusion: Preterm birth significantly affects the peripapillary vascular parameters that indicate higher mVT and narrower mVW in premature infants without ROP. Alterations in these parameters may provide new insights into the pathogenesis of ocular vascular disease.

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利用 U 型网分割技术研究无早产儿视网膜病变的早产儿毛细血管周围参数的变化。

目的：定量评估无早产儿视网膜病变（ROP）的早产儿视盘周围平均血管迂曲度（mVT）和平均血管宽度（mVW）的变化及其与胎龄（GA）和出生体重（BW）的相关性：这是一项单中心回顾性研究，共纳入 133 名（133 只眼）无早产儿视网膜病变的早产儿（平均矫正胎龄（CGA）43.6 周）作为早产儿组，130 名（130 只眼）与 CGA 匹配的足月儿作为对照组。采用计算机辅助技术对毛细血管周围mVT和mVW进行定量测量：早产儿的mVT（P=0.0032）和mVW（P=0.0086）明显较高，分别为2.68 (104 cm-3) 和1.85 µm。用GA进行的亚组分析显示，早产早期组和早产中晚期组之间的mVT差异显著（P=0.0244），但mVW之间的差异不显著（P=0.6652）。多元线性回归模型的结果显示，在调整性别和 CGA 后，GA 和体重与 mVT 呈显著负相关（分别为 P=0.0211 和 P=0.0006）。出生时GA每增加一天，mVT下降0.1281（104 cm-3）；体重每增加1克，mVT下降0.006（104 cm-3）。然而，GA（P=0.9402）和体重（P=0.7275）与 mVW 没有显著相关性：结论：早产会明显影响毛细血管周围参数，这些参数表明未患视网膜病变的早产儿mVT较高，mVW较窄。这些参数的改变可能为眼底血管疾病的发病机制提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of ophthalmology Medicine-Ophthalmology

CiteScore

2.50

自引率

7.10%

发文量

3141

审稿时长

4-8 weeks

期刊介绍： · International Journal of Ophthalmology-IJO (English edition) is a global ophthalmological scientific publication and a peer-reviewed open access periodical (ISSN 2222-3959 print, ISSN 2227-4898 online). This journal is sponsored by Chinese Medical Association Xi’an Branch and obtains guidance and support from WHO and ICO (International Council of Ophthalmology). It has been indexed in SCIE, PubMed, PubMed-Central, Chemical Abstracts, Scopus, EMBASE , and DOAJ. IJO JCR IF in 2017 is 1.166. IJO was established in 2008, with editorial office in Xi’an, China. It is a monthly publication. General Scientific Advisors include Prof. Hugh Taylor (President of ICO); Prof.Bruce Spivey (Immediate Past President of ICO); Prof.Mark Tso (Ex-Vice President of ICO) and Prof.Daiming Fan (Academician and Vice President, Chinese Academy of Engineering. International Scientific Advisors include Prof. Serge Resnikoff (WHO Senior Speciatist for Prevention of blindness), Prof. Chi-Chao Chan (National Eye Institute, USA) and Prof. Richard L Abbott (Ex-President of AAO/PAAO) et al. Honorary Editors-in-Chief: Prof. Li-Xin Xie(Academician of Chinese Academy of Engineering/Honorary President of Chinese Ophthalmological Society); Prof. Dennis Lam (President of APAO) and Prof. Xiao-Xin Li (Ex-President of Chinese Ophthalmological Society). Chief Editor: Prof. Xiu-Wen Hu (President of IJO Press). Editors-in-Chief: Prof. Yan-Nian Hui (Ex-Director, Eye Institute of Chinese PLA) and Prof. George Chiou (Founding chief editor of Journal of Ocular Pharmacology & Therapeutics). Associate Editors-in-Chief include: Prof. Ning-Li Wang (President Elect of APAO); Prof. Ke Yao (President of Chinese Ophthalmological Society) ; Prof.William Smiddy (Bascom Palmer Eye instituteUSA) ; Prof.Joel Schuman (President of Association of University Professors of Ophthalmology,USA); Prof.Yizhi Liu (Vice President of Chinese Ophtlalmology Society); Prof.Yu-Sheng Wang (Director of Eye Institute of Chinese PLA); Prof.Ling-Yun Cheng (Director of Ocular Pharmacology, Shiley Eye Center, USA). IJO accepts contributions in English from all over the world. It includes mainly original articles and review articles, both basic and clinical papers. Instruction is Welcome Contribution is Welcome Citation is Welcome Cooperation organization International Council of Ophthalmology(ICO), PubMed, PMC, American Academy of Ophthalmology, Asia-Pacific, Thomson Reuters, The Charlesworth Group, Crossref,Scopus,Publons, DOAJ etc.