Validation of Ten Osteoporosis Screening Tools in Rural Communities of Taiwan.

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Calcified Tissue International Pub Date : 2024-11-01 Epub Date: 2024-08-18 DOI:10.1007/s00223-024-01273-6
Wen-Tung Hsieh, Tom Maarten Groot, Hung-Kuan Yen, Chen-Yu Wang, Ming-Hsiao Hu, Olivier Q Groot, Ping-Ying Yu, Shau-Huai Fu
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引用次数: 0

Abstract

Purpose: Patients with osteoporosis are at risk of fractures, which can lead to immobility and reduced quality of life. Early diagnosis and treatment are crucial for preventing fractures, but many patients are not diagnosed until after a fracture has occurred. This study aimed to evaluate the performance of 10 osteoporosis screening tools (OSTs) in rural communities of Taiwan. In this prospective study, a total of 567 senior citizens from rural communities underwent bone mineral density (BMD) measurement using dual-energy X-ray absorptiometry (DXA) and ten OSTs were administered. Discrimination analysis was performed using the area under the receiver operating characteristic curve (AUROC). Primary outcomes included area under curve (AUC) value, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). The DXA examination revealed that 63.0% of females and 22.4% of males had osteoporosis. Among females, Osteoporosis Index of Risk (OSIRIS) and Osteoporosis Self-Assessment Tool for Asians (OSTA) presented the best AUC value with 0.71 (0.66-0.76) and 0.70 (0.66-0.75), respectively. Among males, BWC had the best AUC value of 0.77 (0.67-0.86), followed by OSTA, Simple Calculated Osteoporosis Risk Estimation (SCORE), and OSIRIS. OSTA and OSIRIS showed acceptable performance in both genders. The specificity of Fracture Risk Assessment Tool (FRAX-H), SCORE, National Osteoporosis Foundation Score, OSIRIS, Osteoporosis Risk Assessment Instrument, Age, Bulk, One or Never Estrogen (ABONE), and Body weight criteria increased in both genders after applying the optimum cut-off. Considering it high AUC and simplicity of use, OSTA appeared to be the recommended tool for seniors of both genders among the ten OSTs. This study provides a viable reference for future development of OSTs in Taiwan. Further adjustment according to epidemiological data and risk factors is recommended while applying OSTs to different cohorts.

在台湾农村社区验证十种骨质疏松症筛查工具。
目的:骨质疏松症患者有骨折的风险,骨折会导致患者行动不便,生活质量下降。早期诊断和治疗对预防骨折至关重要,但许多患者直到骨折发生后才得到诊断。本研究旨在评估 10 种骨质疏松症筛查工具(OST)在台湾农村社区的表现。在这项前瞻性研究中,共有 567 名来自农村社区的老年人接受了双能 X 射线吸收测量法(DXA)的骨质密度(BMD)测量,并使用了 10 种 OST。使用接收者操作特征曲线下面积 (AUROC) 进行了判别分析。主要结果包括曲线下面积(AUC)值、灵敏度、特异性、阳性预测值(PPV)和阴性预测值(NPV)。DXA 检查显示,63.0% 的女性和 22.4% 的男性患有骨质疏松症。在女性中,骨质疏松症风险指数(OSIRIS)和亚洲人骨质疏松症自我评估工具(OSTA)的AUC值最佳,分别为0.71(0.66-0.76)和0.70(0.66-0.75)。在男性中,BWC的AUC值最佳,为0.77(0.67-0.86),其次是OSTA、简单计算骨质疏松症风险估计(SCORE)和OSIRIS。OSTA 和 OSIRIS 在两性中的表现均可接受。在采用最佳临界值后,骨折风险评估工具(FRAX-H)、SCORE、国家骨质疏松症基金会评分、OSIRIS、骨质疏松症风险评估工具、年龄、体型、使用或从未使用雌激素(ABONE)和体重标准在两性中的特异性都有所提高。考虑到其较高的 AUC 值和使用简便性,在十种 OST 中,OSTA 似乎是针对男女老年人的推荐工具。这项研究为台湾今后开发老年期治疗法提供了可行的参考。建议根据流行病学数据和风险因素作进一步调整,将 OST 应用于不同人群。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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