Validation of a reference interval for symmetric dimethylarginine in healthy goats and its comparison to values in goats with obstructive urolithiasis

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2024-08-17 DOI:10.1111/jvim.17162

Blanca E. Camacho, Siena L. Mitman, Derek M. Foster, Jennifer Halleran

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引用次数: 0

Abstract

Background

Symmetric dimethylarginine (SDMA), a sensitive biomarker for detecting renal injury, has not been characterized in goats. Obstructive urolithiasis (OU) is the most common urinary tract disease in male small ruminants.

Hypothesis/Objective

Establish an SDMA reference interval (RI) in healthy adult goats and describe SDMA concentrations in goats with OU. We hypothesize that the SDMA RI in healthy adult goats will be similar to that of other adult veterinary species and that SDMA can be utilized to assess the renal function of goats experiencing OU.

Animals

Fifty-five healthy adult male and female goats from a university herd were enrolled for SDMA RI development. Twenty male and female goats from a university herd were enrolled for validation of the SDMA RI established. Thirteen male goats diagnosed with OU were enrolled.

Methods

Clinical trial. Serum samples for all animals enrolled were collected and analyzed for SDMA using an immunoassay (IDEXX Laboratories, Inc); goats with OU had additional blood work analyzed (PCV, total solids, and serum biochemistry). Symmetric dimethylarginine and other values in goats with OU were analyzed and compared at specific time points.

Results

The SDMA RI for healthy, adult goats is 8.03 μg/dL (90% CI 4.81-11.04) to 25.93 μg/dL (90% CI 22.88-28.97). There was no correlation identified between serum creatinine and SDMA in goats with OU.

Conclusions and Clinical Importance

The SDMA RI for adult goats is higher than in other adult large animal species. Use of SDMA in goats with OU is not useful in assessing their renal function.

Abstract Image

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验证健康山羊体内对称二甲基精氨酸的参考区间，并将其与患有梗阻性尿路结石的山羊体内的数值进行比较。

背景：对称二甲基精氨酸（SDMA）是一种检测肾损伤的敏感生物标志物，但尚未在山羊中发现其特征。梗阻性尿路结石（OU）是雄性小反刍动物最常见的尿路疾病：建立健康成年山羊的 SDMA 参考区间 (RI)，并描述患有 OU 的山羊体内的 SDMA 浓度。我们假设健康成年山羊的 SDMA RI 与其他成年兽医物种相似，并且 SDMA 可用于评估患有 OU 的山羊的肾功能：55 只来自大学羊群的健康成年公山羊和母山羊参加了 SDMA RI 开发。从一所大学的羊群中挑选了 20 只公羊和母羊，用于验证已建立的 SDMA RI。13只确诊患有OU的雄性山羊也被纳入其中：临床试验。收集所有参试动物的血清样本，并使用免疫测定法（IDEXX Laboratories, Inc）分析SDMA；对患有OU的山羊进行额外的血液分析（PCV、总固形物和血清生化）。在特定的时间点分析并比较了患有 OU 的山羊的对称二甲基精氨酸和其他值：健康成年山羊的 SDMA RI 为 8.03 μg/dL (90% CI 4.81-11.04) 到 25.93 μg/dL (90% CI 22.88-28.97)。结论和临床重要性：成年山羊的SDMA RI高于其他成年大型动物。对患有OU的山羊使用SDMA无法评估其肾功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.