Cerebral-Cerebellar Cortical Activity and Connectivity Underlying Sensory Trick in Cervical Dystonia

IF 4.4 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2024-08-16 DOI:10.1002/acn3.52177

Nai-Qing Cai, Wu-Xiang Shi, Ru-Kai Chen, Bo-Li Chen, Yu-Rong Li, Ning Wang

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Abstract

Objective

The objective of this study was to investigate the activity and connectivity of cerebral and cerebellar cortices underlying the sensory trick (ST) effects in patients with cervical dystonia (CD), using electroencephalography (EEG).

Methods

We recruited 15 CD patients who exhibited clinically effective ST and 15 healthy controls (HCs) who mimicked the ST maneuver. EEG signals and multiple-channel electromyography (EMG) were recorded simultaneously during resting and acting stages. EEG source analysis and functional connectivity were performed. To account for the effects of sensory processing, we calculated relative power changes as the difference in power spectral density between resting and the maneuver execution.

Results

ST induced a decrease in low gamma (30–50 Hz) spectral power in the primary sensory and cerebellar cortices, which remained lower than in HCs during the maintenance period. Compared with HCs, patients exhibited consistently strengthened connectivity within the sensorimotor network during the maintenance period, particularly in the primary sensory-sensorimotor cerebellum connection.

Interpretation

The application of ST resulted in altered cortical excitability and functional connectivity regulated by gamma oscillation in CD patients, suggesting that this effect cannot be solely attributed to motor components. The cerebellum may play important roles in mediating the ST effects.

Abstract Image

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颈性肌张力障碍的大脑-小脑皮层活动和感觉伎俩的连接性

研究目的本研究的目的是利用脑电图（EEG）研究颈性肌张力障碍（CD）患者感觉伎俩（ST）效应所依赖的大脑和小脑皮层的活动和连接性：方法：我们招募了 15 名在临床上表现出有效 ST 的 CD 患者和 15 名模仿 ST 动作的健康对照组（HCs）。我们同时记录了静息和行动阶段的脑电信号和多通道肌电图（EMG）。进行了脑电图信号源分析和功能连接分析。为了考虑感觉处理的影响，我们将相对功率变化计算为静息和动作执行时功率谱密度的差异：结果：ST导致初级感觉皮层和小脑皮层的低伽马（30-50赫兹）频谱功率下降，在维持期仍低于普通人。与普通人相比，患者在维持期的感觉运动网络中表现出持续增强的连通性，尤其是在初级感觉-感觉运动小脑连接中：ST的应用导致CD患者大脑皮层兴奋性和由伽马振荡调节的功能连接发生改变，这表明这种效应不能完全归因于运动成分。小脑可能在介导 ST 效应方面发挥了重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.