Effective treatment of refractory monoclonal gammopathy-associated pure red cell aplasia with isatuximab, pomalidomide and dexamethasone

EJHaem Pub Date : 2024-06-17 DOI:10.1002/jha2.964
Christian Sebastian Michel, Eva Marie Fehr, Hildegard Nolte, Joachim Beck, Andreas Kreft, Katharina Theresa Rauschkolb-Olk, Bjoern Jacobi, Matthias Theobald, Markus Munder
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Abstract

Monoclonal gammopathy-associated pure red cell aplasia (MG-PRCA) is characterized by the absence or pronounced hypoplasia of erythroid precursors in the bone marrow, causing reticulocytopenia and a normocytic, normochromic anaemia in a patient with a monoclonal plasma cell dyscrasia. We report here on the successful treatment of MG-PRCA with isatuximab, pomalidomide, and dexamethasone after multiple lines of immunosuppressive and anti-plasma cell-directed treatments.

Abstract Image

用伊沙妥昔单抗、泊马度胺和地塞米松有效治疗难治性单克隆抗体病相关性纯红细胞再生不良症
单克隆丙种球蛋白病相关性纯红细胞增生症(MG-PRCA)的特点是骨髓中红细胞前体缺失或明显发育不良,导致单克隆浆细胞异常患者出现网织红细胞减少和正常红细胞、正常色素性贫血。我们在此报告了在经过多线免疫抑制和抗浆细胞导向治疗后,使用伊沙妥昔单抗、泊马度胺和地塞米松成功治疗 MG-PRCA 的病例。
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