A Mn-based metal-organic framework Mn-CPP for combined chemodynamic therapy and chemotherapy

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2024-08-11 DOI:10.1016/j.jorganchem.2024.123305

Hongliu Yu , Pengyu Hao , Panpan Si , Bing Wang , Qiying Shen , Hongliang Zhu , Wenxin Lin , Quan Hu

引用次数: 0

Abstract

A Mn-based metal-organic framework Mn-CPP was synthesized and showed excellent chemodynamic therapy (CDT) effect. DOX was selected and loaded into Mn-CPP obtaining DOX@Mn-CPP to improve the therapeutic properties. DOX@Mn-CPP exhibited better drug release behaviors in the tumor environment than that in normal environment. Besides, the material displayed good biocompatibility to L929 cells and significant effect of lethality on 4T1 cells and Hela cells. The successful fabrication of DOX@Mn-CPP provided the potential application for the combination therapy of chemodynamic therapy and chemotherapy.

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用于化学动力疗法和化疗联合疗法的锰基金属有机框架 Mn-CPP

研究人员合成了一种锰基金属有机框架 Mn-CPP，并显示出良好的化学动力学治疗（CDT）效果。研究人员选择 DOX 并将其载入 Mn-CPP，得到 DOX@Mn-CPP，以改善其治疗特性。DOX@Mn-CPP 在肿瘤环境中的药物释放行为优于正常环境。此外，该材料对 L929 细胞具有良好的生物相容性，对 4T1 细胞和 Hela 细胞具有显著的致死效果。DOX@Mn-CPP的成功制备为化学动力疗法和化疗的联合应用提供了可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.

文献相关原料

公司名称	产品信息	采购帮参考价格
麦克林	sodium bicarbonate	￥14.00~￥22434.55
上海源叶	MTT	￥31.00~￥19724.00
麦克林	MnCl?	￥54.00~￥16296.00
麦克林	methylene blue	￥13.00~￥7749.00