Indocyanine green angiography reveals choroidal hypoperfusion in subacute sclerosing panencephalitis (SSPE).

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
European Journal of Ophthalmology Pub Date : 2024-11-01 Epub Date: 2024-08-16 DOI:10.1177/11206721241273563
Aniruddha Agarwal, Parthopratim Dutta Majumder
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引用次数: 0

Abstract

We report the choroidal findings on indocyanine green angiography (ICGA) in two cases of subacute sclerosing panencephalitis (SSPE). The two immunocompetent patients (31-year-old and 30-year-old Asian Indian males) presented with acute-onset rapidly progressing vision loss with findings of necrotizing retinitis involving the central macula. Both patients tested negative for serological evidence of herpes or varicella, and toxoplasma antibodies. The patients demonstrated high serum and cerebrospinal fluid titers of anti-measles antibody (and abnormal electroencephalogram in one patient) leading to the diagnosis of SSPE. ICGA of both patients revealed distinct "dark dots" which showed hypofluorescence in the early and late phases suggestive of choroidal involvement/hypoperfusion. Choroidal involvement in SSPE has not been evaluated before and must be considered in the pathological manifestations of the disease.

靛氰绿血管造影显示亚急性硬化性泛脑炎(SSPE)患者脉络膜灌注不足。
我们报告了两例亚急性硬化性泛脑炎(SSPE)患者吲哚青绿血管造影(ICGA)的脉络膜检查结果。这两名免疫功能正常的患者(分别为 31 岁和 30 岁的亚裔印度男性)表现为急性发作、进展迅速的视力减退,并伴有累及黄斑中心的坏死性视网膜炎。两名患者的疱疹、水痘和弓形虫抗体血清学检测均为阴性。患者血清和脑脊液中抗麻疹抗体滴度较高(其中一名患者脑电图异常),因此被诊断为 SSPE。两名患者的 ICGA 均显示出明显的 "黑点",在早期和晚期显示出荧光减弱,提示脉络膜受累/高灌注。以前从未对 SSPE 的脉络膜受累情况进行过评估,因此必须考虑到该病的病理表现。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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