Unleashing the potential of mRNA: Overcoming delivery challenges with nanoparticles

IF 6.1 2区医学 Q1 ENGINEERING, BIOMEDICAL

Bioengineering & Translational Medicine Pub Date : 2024-08-15 DOI:10.1002/btm2.10713

Qiang Chen, Ku‐Geng Huo, Sheng‐Min Ji, Shu‐De Pang, Tian‐Ying Sun, Yi Niu, Zi‐Hao Jiang, Peng Zhang, Shu‐Xin Han, Jin‐Yao Li

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引用次数: 0

Abstract

Messenger RNA (mRNA) has emerged as a promising therapeutic strategy for various diseases, including cancer, infectious diseases, and genetic disorders. The mRNA‐based therapeutics have gained significant attention due to their ability to regulate targeted cells, activate immune cells, and avoid potential risks associated with DNA‐based technology. However, the clinical application of mRNA in cancer therapy is hindered by the instability of RNA, physiological barriers, and the risk of immunogenic hurdles. To overcome these challenges and ensure the safe delivery of mRNA therapeutics to target sites, nanoparticle‐based delivery systems have been explored as potential tools in vitro and in vivo applications. This review provides a comprehensive overview of the current status of mRNA therapy, discussing its advantages and limitations, delivery strategies and materials, as well as applications in different fields. By exploring these aspects, the researcher can gain a more complete understanding of the current state, prospects, and challenges of mRNA technologies.

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释放 mRNA 的潜力：利用纳米颗粒克服递送难题

信使核糖核酸（mRNA）已成为治疗各种疾病（包括癌症、传染病和遗传性疾病）的一种前景广阔的治疗策略。基于 mRNA 的疗法能够调控靶细胞、激活免疫细胞并避免与 DNA 技术相关的潜在风险，因而备受关注。然而，mRNA 在癌症治疗中的临床应用受到 RNA 不稳定性、生理障碍和免疫原性障碍风险的阻碍。为了克服这些挑战并确保将 mRNA 疗法安全地输送到靶点，人们探索了基于纳米颗粒的输送系统，将其作为体外和体内应用的潜在工具。本综述全面概述了 mRNA 疗法的现状，讨论了其优势和局限性、递送策略和材料以及在不同领域的应用。通过对这些方面的探讨，研究人员可以更全面地了解 mRNA 技术的现状、前景和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioengineering & Translational Medicine Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

8.40

自引率

4.10%

发文量

150

审稿时长

12 weeks

期刊介绍： Bioengineering & Translational Medicine, an official, peer-reviewed online open-access journal of the American Institute of Chemical Engineers (AIChE) and the Society for Biological Engineering (SBE), focuses on how chemical and biological engineering approaches drive innovative technologies and solutions that impact clinical practice and commercial healthcare products.