Effects of chemoradiation and tongue exercise on swallow biomechanics and bolus kinematics.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-08-16 DOI:10.1002/hed.27899

Nicole E Schaen-Heacock, Linda M Rowe, Michelle R Ciucci, John A Russell

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引用次数: 0

Abstract

Background: Common treatments for head and neck cancer (radiation and chemotherapy) can lead to dysphagia; tongue exercise is a common intervention. This study aimed to assess swallow biomechanics and bolus kinematics using a well-established rat model of radiation or chemoradiation treatment to the tongue base, with or without tongue exercise intervention.

Methods: Pre- and post-treatment videofluoroscopy was conducted on 32 male Sprague-Dawley rats treated with radiation/chemoradiation and exercise/no exercise. Rats in the exercise groups completed a progressive resistance tongue training paradigm. Swallow biomechanics, bolus kinematics, jaw opening, and post-swallow respiration were assessed.

Results: Both treatments impacted outcome measures; the addition of exercise intervention showed benefit for some measures, particularly in rats treated with radiation, vs. chemoradiation.

Conclusions: Radiation and chemoradiation can significantly affect aspects of deglutition; combined treatment may result in worse outcomes. Tongue exercise intervention can mitigate deficits; more intensive intervention may be warranted in proportion to combined treatment.

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化疗和舌运动对吞咽生物力学和栓剂运动学的影响

背景：头颈部癌症的常见治疗方法（放疗和化疗）可导致吞咽困难；舌运动是一种常见的干预措施。本研究旨在使用一个成熟的大鼠模型，评估舌根部放疗或化疗治疗后，有无舌运动干预的吞咽生物力学和栓剂运动学：方法：对 32 只雄性 Sprague-Dawley 大鼠进行了治疗前和治疗后的视频荧光镜检查，这些大鼠分别接受了放射/化学放射治疗和运动/不运动治疗。运动组大鼠完成了渐进阻力舌训练范例。对吞咽生物力学、药丸运动学、下颌张开和吞咽后呼吸进行了评估：结果：两种治疗方法都对结果指标产生了影响；增加运动干预对某些指标有益处，尤其是在接受放射治疗的大鼠与化疗大鼠之间：结论：放疗和化疗会严重影响吞咽的各个方面；联合治疗可能会导致更糟的结果。舌部运动干预可减轻缺陷；在联合治疗的情况下，可能需要进行更密集的干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.