WHO global research priorities for antimicrobial resistance in human health

IF 20.9 1区生物学 Q1 INFECTIOUS DISEASES

Lancet Microbe Pub Date : 2024-11-01 DOI:10.1016/S2666-5247(24)00134-4

Silvia Bertagnolio MD , Zlatina Dobreva MSc , Chad M Centner MSc , Ioana Diana Olaru PhD , Daniele Donà PhD , Stefano Burzo PhD , Benedikt D Huttner MD , Antoine Chaillon MD , Nebiat Gebreselassie PhD , Teodora Wi MD , Mateusz Hasso-Agopsowicz PhD , Benedetta Allegranzi MD , Hatim Sati MD , Verica Ivanovska PhD , Kavita U Kothari MPH , Hanan H Balkhy MD , Alessandro Cassini MD , Raph L Hamers PhD , Kitty Van Weezenbeek PhD , Igor Rudan

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引用次数: 0

Abstract

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

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世卫组织人类健康抗菌药耐药性全球研究优先事项。

世界卫生组织人类健康抗菌药物耐药性（AMR）研究议程确定了到 2030 年要解决的 40 个研究重点。这些优先研究重点关注对解决 AMR 问题至关重要的细菌和真菌病原体，包括导致结核病的耐药病原体。这些研究重点涵盖了以人为本的整个过程，包括抗菌药物耐药性感染的预防、诊断和治疗，以及解决 AMR 流行病学、负担和驱动因素、政策和法规以及认识和教育方面的总体知识差距。研究重点是通过多阶段过程确定的，首先是对知识差距进行全面的范围审查，并通过调查和公开呼吁收集专家意见。在确定优先事项时，采用了经过修改的儿童健康与营养研究计划方法，确保研究结果具有全球代表性和适用性。本研究议程的最终目标是鼓励研究和投资于证据的生成，以更好地了解 AMR 的动态，促进政策转化，减轻 AMR 的负担和后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lancet Microbe Multiple-

CiteScore

27.20

自引率

0.80%

发文量

278

审稿时长

6 weeks

期刊介绍： The Lancet Microbe is a gold open access journal committed to publishing content relevant to clinical microbiologists worldwide, with a focus on studies that advance clinical understanding, challenge the status quo, and advocate change in health policy.