Loss to Follow Up Among Glaucoma Patients: An IRIS® Registry (Intelligent Research in Sight) Retrospective Cohort Analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-16 DOI:10.1080/08820538.2024.2391826

Andrew M Williams, Lauren M Wasser, Julie Cassidy, Hsing-Hua Sylvia Lin

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引用次数: 0

Abstract

Purpose: To identify prevalence of and risk factors for loss to follow up (LTFU) among a national cohort of patients with primary open-angle glaucoma (POAG).

Methods: This retrospective cohort study analyzed data from the IRIS® Registry (Intelligent Research in Sight) database from 2014 through 2019 to assess LTFU among adult patients with POAG. POAG patients with at least one clinical encounter in 2014 were included. LTFU was defined as exceeding one year without a clinical encounter during the study period.

Results: Among 553,663 glaucoma patients, 277,019 (50%) became LTFU, of whom 184,548 (67%) never returned to care and 92,471 (33%) re-established follow-up after a lapse. Risk of LTFU was greatest among those younger than 60 years (RR = 1.38; 95% CI: 1.36-1.39) or older than 80 years (RR = 1.39; 95% CI: 1.38-1.40) compared to those in their 60s. Compared to White race, risk for LTFU was highest among Native Hawaiian/Pacific Islander (RR = 1.24; 95% CI: 1.17-1.31), Hispanic ethnicity (RR = 1.19; 95% CI: 1.18-1.20), and Black race (RR = 1.10; 95% CI: 1.09-1.11). Medicare insurance was associated with lower risk of LTFU (RR = 0.79; 95% CI: 0.78-0.79), whereas unknown/missing/no insurance was associated with greater risk (RR = 1.33; 95% CI: 1.32-1.34), compared to private insurance. Compared to mild-stage POAG, risk of LTFU was higher for moderate-stage (RR = 1.10; 95% CI: 1.08-1.13) and severe-stage disease (RR = 1.35; 95% CI: 1.32-1.38).

Conclusion: We found a 50% prevalence of LTFU among POAG patients in the IRIS Registry over a 6-year study period, with greater risk among minority groups and those with more advanced disease.

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青光眼患者失去随访机会：IRIS® Registry（Intelligent Research in Sight）回顾性队列分析。

目的：确定全国原发性开角型青光眼（POAG）患者队列中失去随访（LTFU）的发生率和风险因素：这项回顾性队列研究分析了IRIS® Registry（Intelligent Research in Sight，视力智能研究）数据库2014年至2019年的数据，以评估POAG成年患者的LTFU情况。研究纳入了在 2014 年至少进行过一次临床诊治的 POAG 患者。LTFU的定义是在研究期间超过一年未进行临床诊治：在553,663名青光眼患者中，有277,019人（50%）成为LTFU，其中184,548人（67%）从未重新接受治疗，92,471人（33%）在中断治疗后重新接受随访。与 60 多岁的人相比，60 岁以下（RR = 1.38；95% CI：1.36-1.39）或 80 岁以上（RR = 1.39；95% CI：1.38-1.40）的人发生 LTFU 的风险最大。与白种人相比，夏威夷原住民/太平洋岛民（RR=1.24；95% CI：1.17-1.31）、西班牙裔（RR=1.19；95% CI：1.18-1.20）和黑种人（RR=1.10；95% CI：1.09-1.11）的LTFU风险最高。与私人保险相比，医疗保险与较低的 LTFU 风险相关（RR = 0.79；95% CI：0.78-0.79），而未知/遗漏/无保险与较高的风险相关（RR = 1.33；95% CI：1.32-1.34）。与轻度POAG相比，中度（RR = 1.10; 95% CI: 1.08-1.13）和重度（RR = 1.35; 95% CI: 1.32-1.38）POAG患者的LTFU风险更高：我们发现，在 IRIS 登记处的 6 年研究期间，POAG 患者的 LTFU 患病率为 50%，少数群体和晚期患者的患病风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.