Distinct clinical characteristics of bocavirus and Mycoplasma pneumoniae infection in children plastic bronchitis

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2024-08-16 DOI:10.1002/iid3.1373

Mengqi Liu, Diwei Wei, Tongqiang Zhang, Yongsheng Xu, Wei Guo

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Abstract

Background

This study investigated clinical and laboratory characteristics of human bocavirus type 1 (HBoV1)-plastic bronchiolitis (PB), Mycoplasma pneumoniae (MP)-associated plastic bronchitis (PB) and MP-NPB in children, highlighting inflammation, coagulation, and bronchoscopic needs.

Methods

Data on preschool children with PB during HBoV1 or MP infection were collected, comparing MP-PB to severe Mycoplasma pneumoniae pneumonia.

Result

Compared with the MP-PB group, the HBoV1-PB group, with younger children, had significantly milder clinical symptoms but higher WBC counts (p = .028). The MP-PB group exhibited notably elevated Fibrinogen (p = .045) and d-dimer levels (p < .001). When contrasting the MP-PB with the MP-NPB group, children in MP-PB group still had higher levels of d-dimer and increased inflammatory indicators such as C-reactive protein, procalcitonin, lactate dehydrogenase, and interleukin-6, which were significantly elevated compared with the MP-NPB group. MP-PB showed a higher prevalence of plastic bronchial casts in lower lobes (p = .016) and a dominance of neutrophils in BALF cytology. Additionally, children in the MP-PB group tended to undergo a greater number of bronchoscopies.

Conclusion

This study identifies key differences in plastic bronchitis in children due to HBoV1 and MP, highlighting HBoV1's milder inflammation in younger kids and MP's link to severe inflammatory and coagulation responses, guiding clinical diagnosis and treatment.

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儿童整形性支气管炎中轮状病毒和肺炎支原体感染的不同临床特征。

研究背景本研究调查了人类波卡病毒1型（HBoV1）可塑性支气管炎（PB）、肺炎支原体（MP）相关可塑性支气管炎（PB）和MP-NPB儿童的临床和实验室特征，重点关注炎症、凝血和支气管镜检查需求：方法：收集学龄前儿童在感染 HBoV1 或 MP 时发生塑性支气管炎的数据，将 MP-PB 与重症肺炎支原体肺炎进行比较：结果：与 MP-PB 组相比，HBoV1-PB 组儿童年龄较小，临床症状明显较轻，但白细胞计数较高（p = .028）。MP-PB 组的纤维蛋白原（p = .045）和 d-二聚体水平（p）明显升高：本研究确定了 HBoV1 和 MP 导致的儿童塑性支气管炎的主要差异，强调 HBoV1 在年龄较小的儿童中炎症较轻，而 MP 则与严重的炎症和凝血反应有关，从而为临床诊断和治疗提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology