Thyroid Hormone Receptors Function in GABAergic Neurons During Development and in Adults.

IF 3.8 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrinology Pub Date : 2024-07-26 DOI:10.1210/endocr/bqae101

Frédéric Flamant, Sabine Richard

引用次数: 0

Abstract

The nuclear receptors of thyroid hormone exert a broad influence on brain development and then on adult brain physiology. However, the cell-autonomous function of the receptors is combined with their indirect influence on cellular interactions. Mouse genetics allows one to distinguish between these 2 modes of action. It revealed that 1 of the main cell-autonomous functions of these receptors is to promote the maturation of GABAergic neurons. This review presents our current understanding of the action of thyroid hormone on this class of neurons, which are the main inhibitory neurons in most brain areas.

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甲状腺激素受体在 GABA 能神经元的发育过程中和成年后发挥作用。

甲状腺激素的核受体对大脑的发育和成年后的大脑生理有着广泛的影响。然而，受体的细胞自主功能与其对细胞相互作用的间接影响相结合。小鼠遗传学可以区分这两种作用模式。研究发现，这些受体的主要细胞自主功能之一是促进 GABA 能神经元的成熟。本综述介绍了我们目前对甲状腺激素作用于这类神经元的理解，这类神经元是大多数脑区的主要抑制性神经元。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrinology 医学-内分泌学与代谢

CiteScore

8.10

自引率

4.20%

发文量

195

审稿时长

2-3 weeks

期刊介绍： The mission of Endocrinology is to be the authoritative source of emerging hormone science and to disseminate that new knowledge to scientists, clinicians, and the public in a way that will enable "hormone science to health." Endocrinology welcomes the submission of original research investigating endocrine systems and diseases at all levels of biological organization, incorporating molecular mechanistic studies, such as hormone-receptor interactions, in all areas of endocrinology, as well as cross-disciplinary and integrative studies. The editors of Endocrinology encourage the submission of research in emerging areas not traditionally recognized as endocrinology or metabolism in addition to the following traditionally recognized fields: Adrenal; Bone Health and Osteoporosis; Cardiovascular Endocrinology; Diabetes; Endocrine-Disrupting Chemicals; Endocrine Neoplasia and Cancer; Growth; Neuroendocrinology; Nuclear Receptors and Their Ligands; Obesity; Reproductive Endocrinology; Signaling Pathways; and Thyroid.