Dose–response relationship between computerized cognitive training and cognitive improvement

IF 12.4 1区医学 Q1 HEALTH CARE SCIENCES & SERVICES

NPJ Digital Medicine Pub Date : 2024-08-15 DOI:10.1038/s41746-024-01210-9

Liyang Liu, Haibo Wang, Yi Xing, Ziheng Zhang, Qingge Zhang, Ming Dong, Zhujiang Ma, Longjun Cai, Xiaoyi Wang, Yi Tang

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Abstract

Although computerized cognitive training (CCT) is an effective digital intervention for cognitive impairment, its dose-response relationship is understudied. This retrospective cohort study explores the association between training dose and cognitive improvement to find the optimal CCT dose. From 2017 to 2022, 8,709 participants with subjective cognitive decline, mild cognitive impairment, and mild dementia were analyzed. CCT exposure varied in daily dose and frequency, with cognitive improvement measured weekly using Cognitive Index. A mixed-effects model revealed significant Cognitive Index increases across most dose groups before reaching the optimal dose. For participants under 60 years, the optimal dose was 25 to <30 min per day for 6 days a week. For those 60 years or older, it was 50 to <55 min per day for 6 days a week. These findings highlight a dose-dependent effect in CCT, suggesting age-specific optimal dosing for cognitive improvement.

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计算机化认知训练与认知能力提高之间的剂量-反应关系

尽管计算机化认知训练（CCT）是治疗认知障碍的有效数字干预措施，但其剂量-反应关系却未得到充分研究。这项回顾性队列研究探讨了训练剂量与认知改善之间的关系，以找到最佳的CCT剂量。从2017年到2022年，8709名患有主观认知能力下降、轻度认知障碍和轻度痴呆症的参与者接受了分析。CCT暴露的每日剂量和频率各不相同，每周使用认知指数测量认知改善情况。混合效应模型显示，在达到最佳剂量之前，大多数剂量组的认知指数都有显著提高。对于 60 岁以下的参与者，最佳剂量为每天 25 到 30 分钟，每周 6 天。对于 60 岁或以上的参与者，最佳剂量为每天 50 到 55 分钟，每周 6 天。这些发现凸显了 CCT 的剂量依赖效应，表明针对不同年龄的最佳剂量可改善认知能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Digital Medicine Multiple-

CiteScore

25.10

自引率

3.30%

发文量

170

审稿时长

15 weeks

期刊介绍： npj Digital Medicine is an online open-access journal that focuses on publishing peer-reviewed research in the field of digital medicine. The journal covers various aspects of digital medicine, including the application and implementation of digital and mobile technologies in clinical settings, virtual healthcare, and the use of artificial intelligence and informatics. The primary goal of the journal is to support innovation and the advancement of healthcare through the integration of new digital and mobile technologies. When determining if a manuscript is suitable for publication, the journal considers four important criteria: novelty, clinical relevance, scientific rigor, and digital innovation.