Syntheses and antimicrobial activities of two coordination polymers assembled with AgN and AgO bonds

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2024-08-10 DOI:10.1016/j.ica.2024.122290

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Abstract

Two new coordination polymers ({[Ag(p-phda)₂](BF₄)} _n (1) and {[Ag₂(1,5-nds)(DMSO)₂] DMSO}_n (2) (p-phda: p-phenyldiacetonitrile, 1,5-nds: 1,5-naphthalene disulfonic acid, DMSO: dimethyl sulfoxide) were synthesized and characterized by IR, EA,TG and X-ray single crystal diffraction. 1 was revealed as a 2D “fishing net” assembled by AgN bonds with BF₄⁻ as equilibrium charge. IR and PXRD analysis showed the BF₄⁻ can be irreversibly exchanged by six anions varied in atomic numbers, sizes, configurations and coordination abilities. 2 is constructed by AgO bonds where DMSO function both as guest and bridging ligand. Further diffusion of NO into the solution of 1 and 2 generated two new compounds (1′ and 2′). All four compounds showed excellent broad-spectrum antimicrobial activities against gram-negative bacteria, gram-positive bacteria and yeast. The stronger antibacterial abilities of 1 against S. aureus and P. aeruginosa than those of 2 were evidenced by the smaller minimum inhibitory concentrations of silver ions (AgMICs) and the higher silver ion release rate in aqueous solution. It was concluded that the looser packing of 1 facilitate the silver ions releasing and play a more crucial role than binding mode and ligand-exchangeability. The enhanced P. aeruginosa inhibitions of 1′ and 2′ were elementarily ascribed to NO incorporation, supporting by their increased diameter of inhibition zones and decreased AgMICs.

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用 AgN 和 AgO 键组装的两种配位聚合物的合成与抗菌活性

合成了两种新型配位聚合物（{[Ag(p-phda)2](BF4)} n (1)和 {[Ag2(1,5-nds)(DMSO)2] DMSO}n (2)（p-phda：对苯二乙腈；1,5-nds：1,5-萘二磺酸；DMSO：二甲亚砜）：DMSO：二甲亚砜）的合成，并通过红外、EA、TG 和 X 射线单晶衍射对其进行了表征。结果表明，1 是由 AgN 键组装而成的二维 "渔网"，BF4- 为平衡电荷。红外和 PXRD 分析表明，BF4- 可被六种不同原子数、大小、构型和配位能力的阴离子不可逆地交换。2 由 AgO 键构成，其中 DMSO 既是客体配体，也是桥接配体。NO 进一步扩散到 1 和 2 的溶液中生成了两种新化合物（1′ 和 2′）。这四种化合物对革兰氏阴性菌、革兰氏阳性菌和酵母菌都具有很好的广谱抗菌活性。银离子最小抑菌浓度（AgMICs）较小，银离子在水溶液中的释放率较高，这证明 1 对金黄色葡萄球菌和绿脓杆菌的抗菌能力强于 2。结论是 1 的松散填料有利于银离子的释放，其作用比结合模式和配体交换性更为重要。1′ 和 2′ 对铜绿假单胞菌抑制作用的增强主要归因于 NO 的掺入，抑制区直径的增加和 AgMICs 的减少也证明了这一点。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.