Advances in the Treatment of Pediatric Low-Grade Gliomas.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Current Neurology and Neuroscience Reports Pub Date : 2024-10-01 Epub Date: 2024-08-15 DOI:10.1007/s11910-024-01369-4

Inci Yaman Bajin, Eric Bouffet

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引用次数: 0

Abstract

Purpose of review: Pediatric low-grade gliomas (pLGGs) often result in significant long-term morbidities despite high overall survival rates. This review aims to consolidate the current understanding of pLGG biology and molecular features and provide an overview of current and emerging treatment strategies.

Recent findings: Surgical resection remains a primary treatment modality, supplemented by chemotherapy and radiotherapy in specific cases. However, recent advances have elucidated the molecular underpinnings of pLGGs, revealing key genetic abnormalities such as BRAF fusions and mutations and the involvement of the RAS/MAPK and mTOR pathways. Novel targeted therapies, including MEK, BRAF and pan-RAF inhibitors, have shown promise in clinical trials, demonstrating significant efficacy and manageable toxicity. Understanding of pLGGs has significantly improved, leading to more personalized treatment approaches. Targeted therapies have emerged as effective alternatives, potentially reducing long-term toxicities. Future research should focus on optimizing therapy sequences, understanding long-term impacts, and ensuring global accessibility to advanced treatments.

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小儿低级别胶质瘤的治疗进展。

综述的目的：小儿低级别胶质瘤（pLGGs）尽管总体存活率高，但往往会导致严重的长期发病。本综述旨在巩固当前对 pLGG 生物学和分子特征的认识，并概述当前和新兴的治疗策略：最近的研究结果：手术切除仍是主要的治疗方式，在特定病例中辅以化疗和放疗。然而，最近的研究进展阐明了 pLGGs 的分子基础，揭示了关键的遗传异常，如 BRAF 融合和突变，以及 RAS/MAPK 和 mTOR 通路的参与。包括 MEK、BRAF 和泛 RAF 抑制剂在内的新型靶向疗法已在临床试验中显示出良好的前景，疗效显著，毒性可控。人们对 pLGGs 的认识有了显著提高，从而产生了更加个性化的治疗方法。靶向疗法已成为有效的替代疗法，有可能减少长期毒性。未来的研究应侧重于优化治疗顺序、了解长期影响并确保全球都能获得先进的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.