Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

IF 7.8 1区医学 Q1 Biochemistry, Genetics and Molecular Biology

Aging Cell Pub Date : 2024-08-15 DOI:10.1111/acel.14270

João P. Novo, Lucy Gee, Carolina A. Caetano, Inês Tomé, Andreia Vilaça, Thomas von Zglinicki, Irina S. Moreira, Diana Jurk, Susana Rosa, Lino Ferreira

引用次数: 0

Abstract

BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.

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衰老导致的血脑屏障功能障碍由脑内皮衰老介导。

衰老过程中脑内皮细胞（BEC）功能障碍的特点是其通透性增加和表型改变，包括紧密连接表达失调。在这里，我们研究了 BEC 衰老在 BBB 功能障碍中的作用。我们的研究结果表明，从年轻到衰老的 BBB 过渡至少部分是由 BEC 衰老介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Cell 生物-老年医学

CiteScore

14.40

自引率

2.60%

发文量

212

审稿时长

8 weeks

期刊介绍： Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.