Endothelial cells modulate bone marrow fibrosis

Abstract

Endothelial-cell-specific inactivation of Lats2 or overexpression of YAP1, which are components of the Hippo pathway, induces myofibroblast formation. This leads to extensive fibrosis, osteosclerosis and impaired bone marrow function, and such changes are mediated by endothelial-to-mesenchymal transition. These findings offer insights into potential therapeutic strategies for myelofibrosis and osteosclerosis.