The Kidney in Obesity: Current Evidence, Perspectives and Controversies.

IF 9.5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Obesity Reports Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI:10.1007/s13679-024-00583-y

Dimitris Kounatidis, Natalia G Vallianou, Theodora Stratigou, Maria Voukali, Irene Karampela, Maria Dalamaga

{"title":"The Kidney in Obesity: Current Evidence, Perspectives and Controversies.","authors":"Dimitris Kounatidis, Natalia G Vallianou, Theodora Stratigou, Maria Voukali, Irene Karampela, Maria Dalamaga","doi":"10.1007/s13679-024-00583-y","DOIUrl":null,"url":null,"abstract":"Purpose of review: As obesity and chronic kidney disease (CKD) remain a public health issue, we aim to elaborate on their complex relationship regarding pathogenetic mechanisms and therapeutic potential as well. The purpose of this review is to enhance our understanding of the interplay between obesity and CKD in order to timely diagnose and treat obesity-related CKD.Recent findings: Obesity and CKD pose significant intertwined challenges to global health, affecting a substantial portion of the population worldwide. Obesity is recognized as an independent risk factor, intricately contributing to CKD pathogenesis through mechanisms such as lipotoxicity, chronic inflammation, and insulin resistance. Recent evidence highlights additional factors including hemodynamic changes and intestinal dysbiosis that exacerbate kidney dysfunction in obese individuals, leading to histologic alterations known as obesity-related glomerulopathy (ORG). This narrative review synthesizes current knowledge on the prevalence, pathophysiology, clinical manifestations, and diagnostic strategies of obesity-related kidney disease. Furthermore, it explores mechanistic insights to delineate current therapeutic approaches, future directions for managing this condition and controversies. By elucidating the multifaceted interactions between obesity and kidney health, this review aims to inform clinical practice and stimulate further research to address this global health epidemic effectively.","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":null,"pages":null},"PeriodicalIF":9.5000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Obesity Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13679-024-00583-y","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: As obesity and chronic kidney disease (CKD) remain a public health issue, we aim to elaborate on their complex relationship regarding pathogenetic mechanisms and therapeutic potential as well. The purpose of this review is to enhance our understanding of the interplay between obesity and CKD in order to timely diagnose and treat obesity-related CKD.

Recent findings: Obesity and CKD pose significant intertwined challenges to global health, affecting a substantial portion of the population worldwide. Obesity is recognized as an independent risk factor, intricately contributing to CKD pathogenesis through mechanisms such as lipotoxicity, chronic inflammation, and insulin resistance. Recent evidence highlights additional factors including hemodynamic changes and intestinal dysbiosis that exacerbate kidney dysfunction in obese individuals, leading to histologic alterations known as obesity-related glomerulopathy (ORG). This narrative review synthesizes current knowledge on the prevalence, pathophysiology, clinical manifestations, and diagnostic strategies of obesity-related kidney disease. Furthermore, it explores mechanistic insights to delineate current therapeutic approaches, future directions for managing this condition and controversies. By elucidating the multifaceted interactions between obesity and kidney health, this review aims to inform clinical practice and stimulate further research to address this global health epidemic effectively.

Abstract Image

查看原文本刊更多论文

肥胖症的肾脏：当前证据、观点和争议。

综述的目的：由于肥胖和慢性肾脏病（CKD）仍然是一个公共卫生问题，我们旨在阐述它们在发病机制和治疗潜力方面的复杂关系。本综述旨在加深我们对肥胖与慢性肾脏病之间相互作用的理解，以便及时诊断和治疗与肥胖相关的慢性肾脏病：肥胖和慢性肾脏病对全球健康构成了相互交织的重大挑战，影响着全球相当一部分人口。肥胖被认为是一个独立的风险因素，通过脂肪毒性、慢性炎症和胰岛素抵抗等机制，错综复杂地促成了慢性肾脏病的发病机制。最近的证据表明，包括血流动力学变化和肠道菌群失调在内的其他因素加剧了肥胖者的肾功能障碍，导致了被称为肥胖相关肾小球病（ORG）的组织学改变。这篇叙述性综述综述了目前关于肥胖相关肾病的发病率、病理生理学、临床表现和诊断策略的知识。此外，它还从机理角度探讨了目前的治疗方法、未来的治疗方向以及存在的争议。通过阐明肥胖与肾脏健康之间多方面的相互作用，本综述旨在为临床实践提供参考，并促进进一步的研究，以有效解决这一全球健康流行病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Obesity Reports Medicine-General Medicine

CiteScore

16.40

自引率

1.10%

发文量

期刊介绍： The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.