Exploring Methylphenidate-Induced Intraocular Pressure: A Cautionary Tale in Pediatric ADHD Management.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropharmacology Pub Date : 2024-09-01 Epub Date: 2024-08-02 DOI:10.1097/WNF.0000000000000603

Selman Yıldırım, Mahya Özel, Murat Günay, Esra Hoşoğlu, Bahadir Turan

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引用次数: 0

Abstract

Objectives: This case report explores the intricate relationship between methylphenidate (MTX) use and increased intraocular pressure (IOP) in a pediatric patient with a preexisting history of eye disease. Despite existing literature presenting cases of IOP elevation linked to MTX, a significant gap remains in understanding nuanced risk factors.

Methods: This case study used patients' medical records and a comprehensive literature review.

Results: A 6-year-old girl with attention deficit hyperactivity disorder and a family history of eye conditions exhibited elevated IOP after 12 days of MTX use, prompting discontinuation. The patient successfully transitioned to atomoxetine with normalized IOP and improved attention duration.

Conclusions: Existing cases emphasize the potential link between sympathetic nerve activity and IOP elevation induced by central nervous system stimulants like MTX. Notably, the patient's high hyperopia contributed to the impact of MTX on IOP, suggesting the need for cautious use in susceptible individuals. This case underscores the importance of individualized treatment strategies, particularly in attention deficit hyperactivity disorder patients with family history and additional eye findings, emphasizing safety and comprehensive patient care.

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探索哌醋甲酯诱发的眼内压：小儿多动症管理中的警示故事》。

目的：本病例报告探讨了一名已有眼疾史的儿科患者使用哌醋甲酯（MTX）与眼压升高之间的复杂关系。尽管现有文献介绍了与MTX有关的眼压升高病例，但在了解细微风险因素方面仍存在很大差距：本病例研究使用了患者的医疗记录和全面的文献综述：结果：一名患有注意缺陷多动障碍和家族眼病史的 6 岁女孩在使用 MTX 12 天后出现眼压升高，因此停用了该药。患者成功过渡到阿托西汀治疗后，眼压恢复正常，注意力持续时间也有所改善：现有病例强调了交感神经活动与 MTX 等中枢神经兴奋剂引起的眼压升高之间的潜在联系。值得注意的是，患者的高度远视导致了 MTX 对眼压的影响，这表明需要谨慎使用易感人群。本病例强调了个体化治疗策略的重要性，尤其是对有家族史和其他眼部检查结果的注意力缺陷多动障碍患者，同时强调了安全性和全面的患者护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.