One-carbon footprint in B cells

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2024-08-13 DOI:10.1038/s41589-024-01703-4

Rebekah Steiner, Julia Jellusova

引用次数: 0

Abstract

Dynamic metabolic signatures underpin B cell function throughout development, maturation and differentiation. Germinal center B cells rely on MTHFD2-driven one-carbon metabolism that is dependent on antioxidant availability, purine synthesis and mTORC1 signaling.

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B 细胞中的单碳足迹

在整个发育、成熟和分化过程中，动态代谢特征支撑着 B 细胞的功能。生殖中心 B 细胞依赖于 MTHFD2 驱动的一碳代谢，这种代谢依赖于抗氧化剂的可用性、嘌呤合成和 mTORC1 信号传导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.

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