GENETIC DETERMINANTS OF THROMBOSIS.

Q2 Medicine
Charles J Lowenstein
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引用次数: 0

Abstract

Venous thromboembolism (VTE) is a major cause of morbidity and mortality in the United States. VTE is caused by genetic and acquired conditions, but the genetic variants that increase the risk of VTE are not fully characterized. Recent genome-wide association studies (GWAS) have discovered novel genetic loci linked to VTE. Some of these loci have been characterized, uncovering new pathways that regulate VTE. Functional characterization of candidate genes discovered by GWAS may reveal new therapeutic targets to treat and prevent abnormal thrombosis or bleeding.

血栓形成的遗传决定因素。
在美国,静脉血栓栓塞症(VTE)是发病和死亡的主要原因。VTE 由遗传和后天因素引起,但增加 VTE 风险的遗传变异尚未完全定性。最近的全基因组关联研究(GWAS)发现了与 VTE 相关的新基因位点。其中一些基因位点已被定性,发现了调控 VTE 的新途径。对全基因组关联研究发现的候选基因进行功能鉴定,可能会发现治疗和预防异常血栓形成或出血的新治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
57
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