Anti-ulcerogenic Potential of Kalanchoë gastonis-bonnieri Extracts in Male ICR Mice Model of Ethanol-induced Gastric Ulcers.

IF 3.1 2区农林科学 Q2 CHEMISTRY, APPLIED

Plant Foods for Human Nutrition Pub Date : 2024-12-01 Epub Date: 2024-08-13 DOI:10.1007/s11130-024-01218-2

Abut Antonio García-Pérez, Yessica Casales-Tlatilpa, José Daniel Anaya-Tacuba, Liliana Corona-Oregón, Rosa Angélica Castillo-Rodríguez, Maribel Herrera-Ruiz, Alejandro Zamilpa, Alma Angélica Del Villar-Martínez

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引用次数: 0

Abstract

Peptic ulcers (PU) are a breach in the mucosa of the digestive tract and are related to several factors including an altered immune system and an unbalanced diet. Current treatment carries to long-term complications; therefore, the use of medicinal plants is an alternative for several inflammatory diseases including ulcerative lesions. Kalanchoë gastonis-bonnieri, is a succulent plant and, has been used in traditional medicine against gastric ulcers, inflammation, and cancer among others. The main goal of this work was to analyze the anti-ulcerogenic potential of extracts from leaves of K. gastonis-bonnieri in an assay of ethanol-induced gastric ulcers. An ethanolic extract was obtained by maceration from fresh leaves of K. gastonis-bonnieri, and fractions were obtained through bipartition and chemical fractioning. The chemical characterization of the extract was made through HPLC, GC-MS, and NMR. Total extract and fractions showed an anti-ulcerogenic effect in specimens of male ICR mice with a gastric ulcer index (UI) of 3.27-5.47. The recorded effect is attributed to the presence of terpenoid compounds such as β-Amyrin acetate, which showed antioxidant properties and lessened formations of ulcers induced by ethanol administration in mice stomach.

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加兰草提取物在乙醇诱发胃溃疡的雄性 ICR 小鼠模型中的抗溃疡潜力

消化性溃疡（PU）是消化道粘膜的破损，与多种因素有关，包括免疫系统改变和饮食不均衡。目前的治疗方法会带来长期并发症；因此，使用药用植物是治疗包括溃疡性病变在内的多种炎症性疾病的替代方法。Kalanchoë gastonis-bonnieri 是一种肉质植物，在传统医学中被用于治疗胃溃疡、炎症和癌症等。这项工作的主要目的是在乙醇诱发胃溃疡的试验中分析从 K. gastonis-bonnieri 的叶子中提取的提取物的抗溃疡潜力。通过浸渍从新鲜的胃复春花叶片中提取乙醇提取物，并通过双分馏和化学分馏获得馏分。通过 HPLC、GC-MS 和 NMR 对提取物进行了化学鉴定。总提取物和馏分在雄性 ICR 小鼠标本中显示出抗溃疡作用，胃溃疡指数（UI）为 3.27-5.47。所记录的效果归因于其中的萜类化合物，如 β-Amyrin 乙酸酯，它具有抗氧化特性，能减少乙醇给药诱导的小鼠胃溃疡的形成。

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来源期刊

Plant Foods for Human Nutrition 工程技术-食品科技

CiteScore

6.80

自引率

7.50%

发文量

审稿时长

12-24 weeks

期刊介绍： Plant Foods for Human Nutrition (previously Qualitas Plantarum) is an international journal that publishes reports of original research and critical reviews concerned with the improvement and evaluation of the nutritional quality of plant foods for humans, as they are influenced by: - Biotechnology (all fields, including molecular biology and genetic engineering) - Food science and technology - Functional, nutraceutical or pharma foods - Other nutrients and non-nutrients inherent in plant foods