Effects of isotretinoin on tooth movement, orthodontically induced and non-orthodontic root resorption: A micro-CT study

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-12 DOI:10.1111/ocr.12840

Gulay Dumanli Gok, Koray Halicioglu, Ali Keles, Nejat Vakur Olgac, Damla Kayali, Ozlem Tugce Cilingir Kaya

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引用次数: 0

Abstract

Objectives

This study aims to investigate whether cumulative dose-dependent isotretinoin (Roaccutane®) could affect orthodontic tooth movement (OTM) and root resorption.

Materials and Methods

Ninety male Wistar Albino rats were divided into 4 groups. While, the control (SALINE), solvent (SOYBEAN) and orthodontic drug (ISOTM) groups underwent orthodontic force, the non-orthodontic drug group (ISO) did not. The rats were administrated saline, soybean oil (SBO) and isotretinoin diluted in SBO (ISOTM, ISO) for 30 days, respectively. Six rats were euthanized in each orthodontic group. Fifty grams of orthodontic force was applied to the remaining rats' first molars using the incisors as anchorage. Six more rats in each group were euthanized on the 7th, 14th and 21st days of the force application. In the ISO group, six rats were euthanized on the 37th, 44th and 51st days of administration. Six rats that were euthanized for ISOTM on the 30th day were also used for ISO to reduce the number of rats used. Micro-computed tomography (micro-CT) and histological analysis were performed.

Results

Independent of orthodontic force, isotretinoin caused root resorption in the apical region. However, there was no statistically significant influence of isotretinoin on OTM and orthodontically induced root resorption (OIRR).

Conclusions

Despite the lack of strong evidence supporting the orthodontically induced resorptive effect of isotretinoin, this study provided findings regarding the resorptive effects of isotretinoin on non-orthodontic root resorption. Therefore, the present results underscore the importance of close monitoring during orthodontic treatment to mitigate potential root resorption in patients who use isotretinoin because of acne complaints.

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查看原文本刊更多论文

异维A酸对牙齿移动、正畸诱发和非正畸牙根吸收的影响：显微 CT 和研究。

研究目的本研究旨在探讨累积剂量依赖性异维A酸（Roaccutane®）是否会影响正畸牙齿移动（OTM）和牙根吸收：将 90 只雄性 Wistar 白化大鼠分为 4 组。对照组（生理盐水组）、溶剂组（大豆组）和正畸药物组（ISOTM 组）接受正畸力治疗，非正畸药物组（ISO 组）不接受正畸力治疗。分别给大鼠注射生理盐水、大豆油（SBO）和稀释在 SBO 中的异维A酸（ISOTM，ISO），为期 30 天。每个正畸组有六只大鼠被安乐死。以门牙为锚，对其余大鼠的第一臼齿施加 50 克矫治力。在施力后的第 7 天、第 14 天和第 21 天，每组再有六只大鼠被安乐死。在 ISO 组中，有六只大鼠在施力的第 37、44 和 51 天被安乐死。在 ISO 组中，有六只大鼠在施用 ISOTM 的第 30 天被安乐死，以减少使用的大鼠数量。进行了显微计算机断层扫描（micro-CT）和组织学分析：与正畸力无关，异维A酸会导致根尖区牙根吸收。然而，异维A酸对OTM和正畸诱导的牙根吸收（OIRR）没有统计学意义上的显著影响：尽管缺乏有力的证据支持异维A酸具有正畸诱导的牙根吸收作用，但本研究提供了异维A酸对非正畸牙根吸收的吸收作用。因此，本研究结果强调了在正畸治疗期间进行密切监测以减轻因痤疮而使用异维A酸的患者潜在牙根吸收的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464