LncRNA-encoded peptides in cancer.

IF 29.5 1区 医学 Q1 HEMATOLOGY
Yaguang Zhang
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引用次数: 0

Abstract

Long non-coding RNAs (lncRNAs), once considered transcriptional noise, have emerged as critical regulators of gene expression and key players in cancer biology. Recent breakthroughs have revealed that certain lncRNAs can encode small open reading frame (sORF)-derived peptides, which are now understood to contribute to the pathogenesis of various cancers. This review synthesizes current knowledge on the detection, functional roles, and clinical implications of lncRNA-encoded peptides in cancer. We discuss technological advancements in the detection and validation of sORFs, including ribosome profiling and mass spectrometry, which have facilitated the discovery of these peptides. The functional roles of lncRNA-encoded peptides in cancer processes such as gene transcription, translation regulation, signal transduction, and metabolic reprogramming are explored in various types of cancer. The clinical potential of these peptides is highlighted, with a focus on their utility as diagnostic biomarkers, prognostic indicators, and therapeutic targets. The challenges and future directions in translating these findings into clinical practice are also discussed, including the need for large-scale validation, development of sensitive detection methods, and optimization of peptide stability and delivery.

癌症中的 LncRNA 编码肽。
长非编码 RNA(lncRNA)曾被认为是转录噪音,但现在已成为基因表达的关键调控因子和癌症生物学中的关键角色。最近的突破性研究发现,某些lncRNA可编码小开放阅读框(sORF)衍生的多肽,目前已了解到这些多肽有助于各种癌症的发病机制。这篇综述综述了目前关于癌症中lncRNA编码肽的检测、功能作用和临床意义的知识。我们讨论了在检测和验证 sORFs 方面的技术进步,包括核糖体图谱分析和质谱分析,这些技术进步促进了这些肽的发现。研究还探讨了lncRNA编码的多肽在各类癌症的基因转录、翻译调控、信号转导和代谢重编程等癌症过程中的功能作用。重点介绍了这些多肽作为诊断生物标志物、预后指标和治疗靶点的临床潜力。此外,还讨论了将这些发现转化为临床实践的挑战和未来方向,包括需要进行大规模验证、开发灵敏的检测方法以及优化多肽的稳定性和输送。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
48.10
自引率
2.10%
发文量
169
审稿时长
6-12 weeks
期刊介绍: The Journal of Hematology & Oncology, an open-access journal, publishes high-quality research covering all aspects of hematology and oncology, including reviews and research highlights on "hot topics" by leading experts. Given the close relationship and rapid evolution of hematology and oncology, the journal aims to meet the demand for a dedicated platform for publishing discoveries from both fields. It serves as an international platform for sharing laboratory and clinical findings among laboratory scientists, physician scientists, hematologists, and oncologists in an open-access format. With a rapid turnaround time from submission to publication, the journal facilitates real-time sharing of knowledge and new successes.
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