Effects of indoor environments and outdoor air pollutants in residential areas on acute exacerbation in patients with severe asthma.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-08-12 DOI:10.1080/09603123.2024.2390474

Byung-Keun Kim, Hwan-Cheol Kim, Dong-Wook Lee, Young-Hee Nam, Da Woon Sim, Youngsoo Lee, Ji-Su Shim, Min-Suk Yang, Min-Hye Kim, So Ri Kim, Sang-Heon Kim, Young-Il Koh, Heung-Woo Park

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Abstract

This study aimed to determine the effects of indoor environment (IE) and outdoor air pollutants (OAPs) in residential areas on acute exacerbation (AE) in patients with severe asthma. A total of 115 participants were recruited. To characterize IE, we used structured questionnaires and estimated OAP concentrations using a land-use regression model. Participants who were exposed to passive smoking and lived in houses where the kitchen and living room were not separated showed a significantly higher rate of AE (p = 0.014 and 0.0016, respectively). The mean concentration of PM_2.5 in residential areas during the last 3 years was significantly higher in participants with AE than that in those without AE (19.8 ± 3.1 vs. 21.0 ± 2.5 µg/m³, p = 0.033). Moreover, the serum level of 8-hydroxy-2'-deoxyguanosine significantly increased in participants with AE compared to those without AE (56.9 ± 30.0 vs. 94.7 ± 44.5 ng/mL, p = 0.0047) suggesting enhanced oxidative stress in those with AE.

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住宅区的室内环境和室外空气污染物对严重哮喘患者病情急性加重的影响。

本研究旨在确定住宅区的室内环境（IE）和室外空气污染物（OAPs）对严重哮喘患者急性加重（AE）的影响。我们共招募了 115 名参与者。为了描述 IE 的特征，我们使用了结构化问卷，并使用土地利用回归模型估算了 OAP 的浓度。暴露于被动吸烟环境和居住在厨房与起居室未分开的房屋中的参与者的哮喘发作率明显较高（p = 0.014 和 0.0016）。在过去 3 年中，住宅区 PM2.5 的平均浓度在有 AE 的参与者中明显高于无 AE 的参与者（19.8 ± 3.1 vs. 21.0 ± 2.5 µg/m3，p = 0.033）。此外，与无 AE 的参与者相比，有 AE 的参与者血清中 8- 羟基-2'-脱氧鸟苷水平明显升高（56.9 ± 30.0 vs. 94.7 ± 44.5 ng/mL，p = 0.0047），这表明有 AE 的参与者体内氧化应激增强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.

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