Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

IF 26.6 1区材料科学 Q1 Engineering

Nano-Micro Letters Pub Date : 2024-08-13 DOI:10.1007/s40820-024-01477-3

Qingdong Bao, Xiaoting Zhang, Zhankun Hao, Qinghua Li, Fan Wu, Kaiyuan Wang, Yang Li, Wenlong Li, Hua Gao

引用次数: 0

Abstract

Highlights

Polysaccharide-based microneedles are novel and emerging tools for ocular drug delivery and the research on the diagnosis and treatment of eye diseases is advancing at a fast pace.
Microneedle devices constructed from polysaccharide molecules derived from ocular tissue have the potential to significantly enhance the efficiency of clinical treatments and improve patient compliance with therapeutic regimens.
Guided by our vast clinical experience, this is the first review collates the cutting-edge scientific findings from the interdisciplinary field combining natural macromolecules and ophthalmology.

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治疗眼部疾病的多糖微针系统的进展。

眼睛是一个与全身循环隔绝的复杂器官，由于其保护机制（如血液-视网膜屏障和角膜不透性），给药物输送带来了巨大挑战。传统的给药方法往往无法维持治疗水平，可能会影响患者的安全性和依从性。多糖微针（PSMNs）已成为眼科给药的变革性解决方案。然而，迄今为止还没有关于眼科 PSMNs 的全面综述。在这篇综述中，我们认真研究了多糖化学与微针技术在加强眼部给药方面的协同作用。我们对 PSMN 进行了深入分析，总结了设计原理、制造工艺和制造过程中面临的挑战，包括提高患者的舒适度和依从性。我们还介绍了各种 PSMN 在研究和临床应用中的最新进展和性能。最后，我们回顾了当前与 PSMN 临床和商业发展相关的监管框架和市场障碍，并对这一研究领域提出了最终看法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

32.60

自引率

4.90%

发文量

981

审稿时长

1.1 months

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.