Deciphering Regulatory T-Cell Dynamics in Cancer Immunotherapy: Mechanisms, Implications, and Therapeutic Innovations

IF 4.9 Q1 CHEMISTRY, MEDICINAL

ACS Pharmacology and Translational Science Pub Date : 2024-07-03 DOI:10.1021/acsptsci.4c0015610.1021/acsptsci.4c00156

Sankha Bhattacharya*, Gaurav Paraskar, Megha Jha, Girdhari Lal Gupta and Bhupendra G. Prajapati*,

引用次数: 0

Abstract

This Review explores how tumor-associated regulatory cells (Tregs) affect cancer immunotherapy. It shows how Tregs play a role in keeping the immune system in check, how cancers grow, and how well immunotherapy work. Tregs use many ways to suppress the immune system, and these ways are affected by the tumor microenvironment (TME). New approaches to cancer therapy are showing promise, such as targeting Treg checkpoint receptors precisely and using Fc-engineered antibodies. It is important to tailor treatments to each patient’s TME in order to provide personalized care. Understanding Treg biology is essential for creating effective cancer treatments and improving the long-term outcomes of immunotherapy.

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解密癌症免疫疗法中的调节性 T 细胞动态：机制、影响和治疗创新

这篇综述探讨了肿瘤相关调节细胞（Tregs）如何影响癌症免疫疗法。它说明了Tregs如何在控制免疫系统、癌症如何生长以及免疫疗法如何发挥作用。肿瘤调节细胞通过多种方式抑制免疫系统，而这些方式都会受到肿瘤微环境（TME）的影响。癌症治疗的新方法正显示出希望，例如精确靶向 Treg 检查点受体和使用 Fc 工程抗体。重要的是要根据每位患者的 TME 量身定制治疗方案，以提供个性化治疗。了解 Treg 的生物学特性对于创造有效的癌症疗法和改善免疫疗法的长期疗效至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Pharmacology and Translational Science Medicine-Pharmacology (medical)

CiteScore

10.00

自引率

3.30%

发文量

133

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