Oncogenomics in the classification of mature B-and T-cell lymphomas: where are we now?

Abstract

Our understanding of the molecular aberrations in lymphoma, has been revolutionized by large scale sequencing studies, which has identified genetic mutations, transcriptional states and epigenetic dysregulation that define key subtypes with distinct biological properties and outcomes. Herein we provide an introduction to these findings, with a focus on mature B and T cell neoplasms, and discuss their significance in this vast and immensely fast moving field.