Development of surface plasmon resonance sensor utilizing GaSe and WS2 for ultra-sensitive early detection of dengue virus

IF 3.1 3区物理与天体物理 Q2 Engineering

Optik Pub Date : 2024-07-31 DOI:10.1016/j.ijleo.2024.171975

Virendra Kumar , Rajeev Kumar , Sarika Pal , Yogendra Kumar Prajapati

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引用次数: 0

Abstract

This manuscript introduces highly sensitive surface plasmon resonance (SPR) sensor for early detection of the dengue virus. Through extensive optimization using MATLAB, the sensor architecture is meticulously constructed with a BK7 prism, Copper (Cu) layer, Gallium selenide (GaSe), Tungsten disulphide (WS₂), and a sensing medium (SM) containing blood components (infected platelets and normal platelets) to ensure optimal performance. Use of WS₂ emerges as a highly effective biomolecular recognition element (BRE) layer, leading to exceptional sensor capabilities. The proposed sensor achieves a peak sensitivity (S) of 303.28 (˚/RIU) and a resonance angle shift (∆θ_res.) of 10˚ specifically during the detection of infected platelets. Computational modeling using COMSOL Multiphysics validates the ability of the sensor to generate an intense electric field with a magnitude of 1.68×10⁵ (V/m) and a penetration depth (PD) extending to 153.24 nm in the SM. This unique combination of PD and enhanced performance parameters positions the proposed SPR biosensor as a promising tool for the early-stage detection of the dengue virus.

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利用 GaSe 和 WS2 开发表面等离子体共振传感器，用于登革热病毒的超灵敏早期检测

本手稿介绍了用于早期检测登革热病毒的高灵敏度表面等离子体共振（SPR）传感器。通过使用 MATLAB 进行广泛优化，传感器结构由 BK7 棱镜、铜（Cu）层、硒化镓（GaSe）、二硫化钨（WS2）和含有血液成分（受感染血小板和正常血小板）的传感介质（SM）精心构建而成，以确保最佳性能。WS2 是一种高效的生物分子识别元件 (BRE) 层，具有卓越的传感器功能。所提出的传感器在检测受感染血小板时的峰值灵敏度 (S) 达到 303.28（˚/RIU），共振角偏移 (∆θres.) 为 10˚。使用 COMSOL Multiphysics 进行的计算建模验证了传感器在 SM 中产生 1.68×105 (V/m) 强电场和 153.24 nm 穿透深度 (PD) 的能力。这种穿透深度和增强性能参数的独特组合使所提出的 SPR 生物传感器成为登革热病毒早期检测的理想工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Optik 物理-光学

CiteScore

6.90

自引率

12.90%

发文量

1471

审稿时长

46 days

期刊介绍： Optik publishes articles on all subjects related to light and electron optics and offers a survey on the state of research and technical development within the following fields: Optics: -Optics design, geometrical and beam optics, wave optics- Optical and micro-optical components, diffractive optics, devices and systems- Photoelectric and optoelectronic devices- Optical properties of materials, nonlinear optics, wave propagation and transmission in homogeneous and inhomogeneous materials- Information optics, image formation and processing, holographic techniques, microscopes and spectrometer techniques, and image analysis- Optical testing and measuring techniques- Optical communication and computing- Physiological optics- As well as other related topics.