A. A. Luenkova, I. A. Doroshenko, T. A. Podrugina, M. K. Beklemishev
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Abstract
For the purpose of imaging hydrophilic drugs, aggregates of gentamicin and vinorelbine with carbocyanine dyes fluorescing in the near-infrared region of the spectrum and a laurate ion as a counterion are obtained. To isolate the aggregates, precipitation from an aqueous solution of components is used. The size of the aggregates with gentamicin range from 200 to 600 nm; with vinorelbine, from 400 to 1000 nm; the surface ζ potential varies in the range of –15…–5 mV. The aggregates are sorbed by the subcutaneous fatty tissue, muscle, bone, and endothelial tissues of chickens. In the future, the resulting aggregates can be used to visualize drug delivery to the tissues of living organisms.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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