Ixekizumab Improved Refractory Erythrodermic Psoriasis with Comorbid Diffuse Alopecia: A Case Report with 52-Week Follow-Up

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-08 DOI:10.2147/ccid.s471582

Biao Song, Xiaohan Liu, Hongzhong Jin

引用次数: 0

Abstract

Abstract: Erythrodermic psoriasis (EP) is a severe and rare variant of psoriasis, accounting for less than 3% of cases. It is characterized by widespread scaling and erythema that affects more than 90% of the body surface area. Alopecia can manifest as a symptom associated with the disease, further exacerbating the impact on the patient’s quality of life. We present the case of a patient with severe EP and diffuse alopecia who did not respond to conventional therapies. The patient was subsequently treated with ixekizumab as per labeled usage, resulting in complete resolution of both psoriatic skin lesions (Psoriasis area and severity index/PASI 100) and alopecia (The Severity of Alopecia Tool/SALT 0).

Keywords: erythrodermic psoriasis, alopecia, ixekizumab

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伊昔单抗改善了伴有弥漫性脱发的难治性红皮病型银屑病：随访 52 周的病例报告

摘要：红皮病型银屑病（EP）是银屑病的一种严重而罕见的变异型，发病率不到 3%。其特征是广泛的鳞屑和红斑，影响超过 90% 的体表面积。脱发可能是与该病相关的一种症状，进一步加剧了对患者生活质量的影响。我们介绍了一例患有严重 EP 和弥漫性脱发且对传统疗法无效的患者。随后，该患者按照标签上的用法接受了ixekizumab治疗，结果银屑病皮损（银屑病面积和严重程度指数/PASI 100）和脱发（脱发严重程度工具/SALT 0）均完全消退。关键词：红皮病型银屑病；脱发；ixekizumab

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.