Synthesis, Spectral, and Structural Investigations and Anticancer Activity In Vitro of the New Organotin Complexes

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2024-08-06 DOI:10.1134/S1990750824600109

P. A. Storozhenko, I. S. Veselova, E. V. Ovechkina, A. A. Grachev, A. A. Korlyukov, A. D. Volodin, E. Yu. Rybalkina, A. K. Shestakova, V. I. Shiryaev

引用次数: 0

Abstract

The series of new organotin complexes on the basis of bis(trimethylsilylmethyl)tin diсhloride, 1,1-dichloro-1-stanna-3,3,5,5-tetramethyl-3,5-disila-4-oxacyclohexane, and mono- and bidentate ligands—2,2'-bipyridyl, 1,10-phenanthroline, and 1-methyl-, 1-vinyl-, and 1-allylimidazoles—have been synthesized. The complexes were characterized by elemental analysis; ¹Н-, ¹³С-, and ¹¹⁹Sn-NMR spectrometry; and X-ray data. Cytotoxicity in vitro of the complexes for some lines of human cancer cells was investigated.

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新型有机锡配合物的合成、光谱和结构研究及体外抗癌活性

摘要在双(三甲基硅甲基)二氯化锡、1,1-二氯-1-链烷-3,3,5,5-四甲基-3,5-二氮杂-4-氧杂环己烷、单双配体-2,2'-联吡啶、1,10-菲罗啉、1-甲基、1-乙烯基和 1-烯丙基咪唑的基础上，合成了一系列新的有机锡配合物。这些复合物通过元素分析、1Н-、13С- 和 119Sn-NMR 光谱法以及 X 射线数据进行了表征。研究了这些复合物在体外对一些人类癌细胞的细胞毒性。

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来源期刊

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.