Development of dual-effect AW/Ag/CHI bioactive and antibacterial coating for orthopedic implant surfaces

IF 3 3区工程技术 Q2 CHEMISTRY, ANALYTICAL

Journal of Thermal Analysis and Calorimetry Pub Date : 2024-08-06 DOI:10.1007/s10973-024-13488-8

Serbülent Türk, Eren Yılmaz, Alican Bahadır Semerci, Mine Kırkbınar, Erhan İbrahimoğlu, Fatih Çalışkan

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Abstract

Titanium implants, which are widely used in orthopedic implant applications, require surface treatments due to their low osteoinduction properties and the risk of postoperative infection. In this study, apatite wollastonite (AW)-based coatings with chitosan (CHI) and silver (Ag) added were applied to the titanium surface using dip coating and drop casting techniques. The obtained coating surfaces were characterized by FESEM, EDS, XRD, FTIR, and TGA–DSC. Biomineralization behaviors were examined by immersing the resulting coatings in simulated body fluid with pH 7.2–7.4. The antibacterial activities of the coatings obtained using S. aureus and E. coli bacterial colonies were examined. Following the successful coating of AW nanoparticles on the Ag and CHI implant substrate, the Ca/P ratio of the coated surface was obtained as 1.4–1.92% after the biomineralization process performed at 37° for 7 days. Ag particles were successfully distributed homogeneously with a 40–50-nm diameter in Ag-doped coatings. It was concluded that the successfully produced composite coating with bioactive and antibacterial properties is a suitable candidate material for metallic implant surfaces.

Graphical abstract

Abstract Image

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为骨科植入物表面开发双效 AW/Ag/CHI 生物活性抗菌涂层

钛植入物广泛应用于骨科植入物，由于其骨诱导特性较低，且存在术后感染的风险，因此需要对其进行表面处理。在这项研究中，采用浸涂和滴注技术将添加了壳聚糖（CHI）和银（Ag）的硅灰石（AW）基磷灰石涂层应用于钛表面。通过 FESEM、EDS、XRD、FTIR 和 TGA-DSC 对所获得的涂层表面进行了表征。将所得涂层浸入 pH 值为 7.2-7.4 的模拟体液中，对其生物矿化行为进行了检测。使用金黄色葡萄球菌和大肠杆菌菌落检测了涂层的抗菌活性。将 AW 纳米粒子成功涂覆在 Ag 和 CHI 种植体基底上后，在 37° 下进行 7 天的生物矿化过程后，涂覆表面的 Ca/P 比值为 1.4-1.92%。在掺银涂层中，银颗粒以 40-50 纳米的直径均匀分布。结论是，成功制备的具有生物活性和抗菌特性的复合涂层是金属植入物表面的合适候选材料。

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来源期刊

Journal of Thermal Analysis and Calorimetry 化学-分析化学

CiteScore

8.50

自引率

9.10%

发文量

577

审稿时长

3.8 months

期刊介绍： Journal of Thermal Analysis and Calorimetry is a fully peer reviewed journal publishing high quality papers covering all aspects of thermal analysis, calorimetry, and experimental thermodynamics. The journal publishes regular and special issues in twelve issues every year. The following types of papers are published: Original Research Papers, Short Communications, Reviews, Modern Instruments, Events and Book reviews. The subjects covered are: thermogravimetry, derivative thermogravimetry, differential thermal analysis, thermodilatometry, differential scanning calorimetry of all types, non-scanning calorimetry of all types, thermometry, evolved gas analysis, thermomechanical analysis, emanation thermal analysis, thermal conductivity, multiple techniques, and miscellaneous thermal methods (including the combination of the thermal method with various instrumental techniques), theory and instrumentation for thermal analysis and calorimetry.