Sustained-Release of Antigens and CpG-DNA using Temperature-Responsive Biodegradable Injectable Polymers: Performance on Induction of Immune Responses (Adv. Therap. 8/2024)

Abstract

Temperature-responsive biodegradable injectable polymer (IP) hydrogel attains sustained-release of antigens and adjuvants persistently stimulating antigen-presenting cells. The degradability of IP hydrogels is adjustable by using tri-PCG whose termini are chemically modified. The release behavior of antigens and adjuvants is controlled by changing the composition of the injectable polymer system. Cellular and humoral responses induced by IP hydrogel vaccine formulations are investigated and discussed herein. More details can be found in article 2300296 by Yuta Yoshizaki, Yuichi Ohya, and co-workers.