Synthesis of cyclic sulfamides via one pot alkylation/aza-Michael cascade reaction

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2024-07-31 DOI:10.1016/j.tetlet.2024.155213

引用次数: 0

Abstract

A straightforward and transition metal-free method for the synthesis of cyclic sulfamides via base-promoted bis-alkylation of tert-butyl (N-alkylsulfamoyl)carbamates with electron-deficient allyl bromides is described. All obtained cyclic sulfamides underwent successful removal of tert-butoxycarbonyl protecting group.

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通过一锅烷基化/扎-迈克尔级联反应合成环状氨基磺酸

本文介绍了一种通过碱促进-丁基（-烷基氨基磺酰基）氨基甲酸酯与缺电子的烯丙基溴进行双烷基化合成环状氨基磺酸的直接且无过渡金属的方法。所有获得的环状氨基磺酸都成功地去除了-丁氧羰基保护基。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.