Jie Wang, Jiaqi Li, Yinan Sun, Xing Liu, Liping Wang, Yan Xia, Jinxia Huang, Jian Feng, Shuang Jia, Yimiao Li, Zhao Guo, Yuxin Dong, Liyao Wang, Xinyu Li
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引用次数: 0
Abstract
The role of interferon-alpha is critical in modulating immune responses and the wound healing process. However, the rapid degradation and short lifespan of IFN-α in the body limit its therapeutic efficacy in wound management. This study presents an innovative approach to enhancing diabetic wound repair through the incorporation of IFN-α into double network hydrogels composed of hyaluronic acid and collagen-like protein (CLP). Two incorporation methods were evaluated: genetic fusion and spy-chemistry ligation. Our results demonstrate that IFN-α incorporated via spy-chemistry significantly outperformed genetic fusion in terms of cell viability, migration, and protein expression. In vivo studies further confirmed that spy-chemistry ligated IFN-α HA-CLP hydrogels markedly improved wound healing, as evidenced by elevated levels of COL-1α, CK-14, and α-SMA, compared to blank HA-CLP hydrogels and saline-treated controls. These findings underscore the potential of spy-chemistry ligated IFN-α-HA-CLP hydrogels as a promising therapeutic strategy for promoting effective wound healing in diabetic patients.
期刊介绍:
ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.