(±)-Mucroniferal D: a Pair of New Phenolic Enantiomers from Corydalis mucronifera

Abstract

Chemical investigation of Corydalis mucronifera has resulted in the isolation and identification of a pair of new enantiomeric phenolic constituents (±)-mucroniferal D (1) and five known ones (2–6). Their structures were elucidated based on extensive spectroscopic data analysis of MS, 1D and 2D NMR, and their absolute configurations were confirmed by comparison of the optical rotation data. Compounds 1–6 showed moderate cytotoxic activities against MCF-7, MGC-803, and HeLa cell lines with the IC₅₀ values ranging from 22.61–98.30 μg·mL^–1.