Anti-TMV activity of flavonol derivatives containing piperidine sulfonamide: Design, synthesis, mechanism study

IF 5.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Arabian Journal of Chemistry Pub Date : 2024-07-31 DOI:10.1016/j.arabjc.2024.105944

Zhiling Sun, Wei Zeng, Qing Zhou, Yujiao Qiu, Yuzhi Hu, Jieyu Li, Hong Fu, Hongqian Zou, Wei Xue

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引用次数: 0

Abstract

A series of flavonol derivatives containing piperidine sulfonamide were designed and synthesized. The EC₅₀ values for the curative of tobacco mosaic virus (TMV) by Z6 and Z22 were 108.2 and 102.7 μg/mL, respectively, outperforming the control agent ningenmycin (NNM) with an EC₅₀ value of 253.8 μg/mL. Additionally, the EC₅₀ values for the protective activity of Z6 and Z21 were 100.9 and 123.2 μg/mL, respectively, also surpassing the control agent NNM with an EC₅₀ value of 203.7 μg/mL. Microscale thermophoresis (MST) and molecular docking test showed that Z6 bound well with tobacco mosaic virus coat protein (TMV-CP). The biological safety test showed that Z6 had almost no effect on seed germination and seedling growth. After treatment with Z6, the chlorophyll content and superoxide dismutase (SOD) activity in tobacco leaves increased, while the malondialdehyde (MDA) content decreased. Therefore, Z6 has a high probability as a potential antiviral agent.

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含哌啶磺酰胺的黄酮醇衍生物的抗 TMV 活性：设计、合成和机理研究

设计并合成了一系列含有哌啶磺酰胺的黄酮醇衍生物。和对烟草花叶病毒（TMV）的有效浓度值分别为 108.2 和 102.7 g/mL，优于对照药宁宁霉素（NNM）的 253.8 g/mL。此外，和的保护活性 EC 值分别为 100.9 和 123.2 g/mL，也超过了对照药剂 NNM（EC 值为 203.7 g/mL）。微尺度热泳（MST）和分子对接试验表明，和与烟草花叶病毒衣壳蛋白（TMV-CP）结合良好。生物安全性测试表明，对种子萌发和幼苗生长几乎没有影响。烟草叶片中叶绿素含量和超氧化物歧化酶（SOD）活性增加，丙二醛（MDA）含量降低。因此，它很有可能成为一种潜在的抗病毒剂。

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来源期刊

Arabian Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

10.80

自引率

3.30%

发文量

763

审稿时长

63 days

期刊介绍： The Arabian Journal of Chemistry is an English language, peer-reviewed scholarly publication in the area of chemistry. The Arabian Journal of Chemistry publishes original papers, reviews and short reports on, but not limited to: inorganic, physical, organic, analytical and biochemistry. The Arabian Journal of Chemistry is issued by the Arab Union of Chemists and is published by King Saud University together with the Saudi Chemical Society in collaboration with Elsevier and is edited by an international group of eminent researchers.