Novel Green Aqueous Two-Phase Systems (ATPSs) based on choline salts and application to the removal of pharmaceutical pollutants from water

IF 2.8 3区工程技术 Q3 CHEMISTRY, PHYSICAL

Fluid Phase Equilibria Pub Date : 2024-07-29 DOI:10.1016/j.fluid.2024.114193

Leonor R. Barroca , Pedro Velho , Eugénia A. Macedo

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引用次数: 0

Abstract

Aqueous Two-Phase Systems (ATPSs) constitute extractive media with applicability for the removal of a wide range of solutes, such as antioxidants or pharmaceuticals, and can be designed in a non-toxic and environmentally friendly manner. Nevertheless, prior to their general use at large scale, their liquid-liquid equilibria (solubility curves and tie-line compositions) need to be thoroughly determined.

In this work, 6 solubility curves were obtained for novel aqueous ternary systems containing choline salts (choline chloride, choline bicarbonate, choline (2R,3R)-bitartrate and choline di-hydrogen citrate) and either ethyl lactate (EL) or polyethylene glycol (PEG), at 298.15 K and 0.1 MPa. Moreover, 3 tie-line compositions were successfully determined for the system {ethyl lactate (1) + choline (2R,3R)-bitartrate (2) + water (3)}. Then, this novel ATPS was applied in the removal of three common pharmaceutical pollutants from aqueous media (acetaminophen, amoxicillin and salicylic acid). In these partition studies, salicylic acid and acetaminophen were effectively extracted to the top phase, with the highest partition coefficients ( $K = 9 \pm 2)$ being obtained for salicylic acid in the longest tie-line (length of 0.8816). Acetaminophen achieved the most promising results ( $K = 2.2 \pm 0.1$ ) in the shortest tie-line (length of 0.6192).

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基于胆碱盐的新型绿色水基两相系统（ATPS）及其在去除水中药物污染物中的应用

水基两相体系（ATPS）是一种萃取介质，适用于去除抗氧化剂或药物等多种溶质，并且可以无毒、环保的方式进行设计。不过，在大规模使用之前，需要彻底确定其液液平衡（溶解度曲线和连接线成分）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fluid Phase Equilibria 工程技术-工程：化工

CiteScore

5.30

自引率

15.40%

发文量

223

审稿时长

53 days

期刊介绍： Fluid Phase Equilibria publishes high-quality papers dealing with experimental, theoretical, and applied research related to equilibrium and transport properties of fluids, solids, and interfaces. Subjects of interest include physical/phase and chemical equilibria; equilibrium and nonequilibrium thermophysical properties; fundamental thermodynamic relations; and stability. The systems central to the journal include pure substances and mixtures of organic and inorganic materials, including polymers, biochemicals, and surfactants with sufficient characterization of composition and purity for the results to be reproduced. Alloys are of interest only when thermodynamic studies are included, purely material studies will not be considered. In all cases, authors are expected to provide physical or chemical interpretations of the results. Experimental research can include measurements under all conditions of temperature, pressure, and composition, including critical and supercritical. Measurements are to be associated with systems and conditions of fundamental or applied interest, and may not be only a collection of routine data, such as physical property or solubility measurements at limited pressures and temperatures close to ambient, or surfactant studies focussed strictly on micellisation or micelle structure. Papers reporting common data must be accompanied by new physical insights and/or contemporary or new theory or techniques.